https://scholars.lib.ntu.edu.tw/handle/123456789/468910
DC Field | Value | Language |
---|---|---|
dc.contributor.author | CHUNG-WU LIN | en_US |
dc.contributor.author | Yang J.-Y. | en_US |
dc.contributor.author | Chuang Y.-C. | en_US |
dc.contributor.author | Chen Y.-H. | en_US |
dc.contributor.author | Albitar M. | en_US |
dc.contributor.author | Hsu S.-M. | en_US |
dc.creator | Chung-Wu Lin;Yang J.-Y.;Chuang Y.-C.;Chen Y.-H.;Albitar M.;Hsu S.-M. | - |
dc.date.accessioned | 2020-03-03T03:36:55Z | - |
dc.date.available | 2020-03-03T03:36:55Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0023-6837 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037239403&doi=10.1097%2f01.LAB.0000047491.62596.A3&partnerID=40&md5=7d0e2ce095a26ef3ee183a6b088711b1 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/468910 | - |
dc.description.abstract | Most sinonasal lymphomas have a restricted killer immunoglobulin-like receptor (KIR) repertoire without a monoclonal T-cell receptor-γ (TCR-γ) rearrangement, implying an NK lineage. However, the lineage assignment of sinonasal lymphoma with a monoclonal TCR-γ rearrangement is unclear because of its mixed NK/T phenotype. The possibility of a mixed NK/T lineage arises with the discovery of T cells with NK features, such as KIR+ T cells or Vα24+ NKT cells. The former might transform into a T-cell lymphoma with both a monoclonal TCR-γ rearrangement and a restricted KIR repertoire; the latter might give rise to a T-cell lymphoma with a monoclonal Vα24 rearrangement and possibly a restricted KIR repertoire. To identify such mixed-lineage lymphomas, we undertook a survey of 15 consecutive sinonasal lymphomas and found six with both a restricted KIR repertoire and a monoclonal TCR-γ rearrangement, consistent with KIR+ T-cell lymphomas. Among these six cases, four female CD56-/CD44-/CD8-/CD45RO+/ CD45RA- cases constituted a distinct group with a better prognosis than the rest of the male cases of sinonasal lymphomas. None of the six cases had a monoclonal Vα24 repertoire, thus excluding a derivation from NKT cells. The predominance of KIR+ T cells that normally function in chronic viral infections over Vα24+ NKT cells that typically recognize glycolipid antigens is consistent with the known association of Epstein-Barr virus infection with sinonasal lymphoma. The demonstration of mixed lineage in a mature lymphoid neoplasm is unusual and echoes the World Health Organization classification that placed NK-cell and T-cell lymphomas in a mixed group. | - |
dc.publisher | Lippincott Williams and Wilkins | - |
dc.relation.ispartof | Laboratory Investigation | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | CD45 antigen; CD56 antigen; CD8 antigen; Hermes antigen; immunoglobulin receptor; protein subunit; T lymphocyte receptor gamma chain; adolescent; adult; aged; antigen binding; article; cellular immunity; clinical article; clinical feature; controlled study; disease association; Epstein Barr virus; female; gene rearrangement; genetic linkage; health survey; human; immunopathology; lymphocyte differentiation; lymphoma; male; mixed cell culture; natural killer cell; nose tumor; paranasal sinus tumor; phenotype; priority journal; prognosis; protein expression; receptor gene; virus infection; world health organization | - |
dc.title | Presence of restricted killer immunoglobulin-like receptor repertoire and monoclonal T-cell receptor γ rearrangement as evidence of mixed NK/T-cell differentiation in a subset of sinonasal lymphomas | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1097/01.LAB.0000047491.62596.A3 | - |
dc.identifier.pmid | 12533686 | - |
dc.identifier.scopus | 2-s2.0-0037239403 | - |
dc.relation.pages | 55-64 | - |
dc.relation.journalvolume | 83 | - |
dc.relation.journalissue | 1 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Pathology | - |
crisitem.author.orcid | 0000-0001-5042-0503 | - |
crisitem.author.parentorg | College of Medicine | - |
Appears in Collections: | 病理學科所 |
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