https://scholars.lib.ntu.edu.tw/handle/123456789/469774
Title: | The impact of chronic kidney disease on lipid management and goal attainment in patients with atherosclerosis diseases in Taiwan | Authors: | Lin T.-H. Chuang S.-Y. Chu C.-Y. Lee W.-H. Hsu P.-C. Su H.-M. Li Y.-H. Fang C.-C. Wang K.-Y. Tseng W.-K. Li A.-H. Ueng K.-C. Hsieh I.-C. Huang L.-C. Wang C.-H. Pan W.-H. Yeh H.-I. CHAU-CHUNG WU Yin W.-H. Chen J.-W. |
Keywords: | Atherosclerosis; Chronic kidney disease; Goal; Lipid | Issue Date: | 2014 | Publisher: | Ivyspring International Publisher | Journal Volume: | 11 | Journal Issue: | 4 | Start page/Pages: | 381-388 | Source: | International Journal of Medical Sciences | Abstract: | Background: Patients with chronic kidney disease (CKD) is a very high risk cardiovascular disease population and should be treated aggressively. We investigated lipid management in CKD patients with atherosclerosis in Taiwan. Methods: 3057 patients were enrolled in a multi-center study (T-SPARCLE). Lipid goal are defined as total cholesterol (TC) < 160mg/dl, low-density lipoprotein (LDL) <100 mg/dl, high-density lipoprotein (HDL) > 40 mg/dl in men, HDL > 50 mg/dl in women, non-HDL cholesterol < 130mg/dl, and triglyceride < 150 mg/dl. Results: Compared with those without CKD (n=2239), patients with CKD (n=818) had more co-morbidities (hypertension, glucose intolerance, stroke and heart failure) and lower HDL but higher triglyceride levels. Overall 2168 (70.5%) patients received lipid-lowering agents. There was similar equivalent statin potency between CKD and non-CKD groups. The goal attainment is lower in HDL and TG in the CKD group as compared with non-CKD subjects (47.1 vs. 51.9% and 63.2 vs. 68.9% respectively, both p < 0.02). Analysis of sex and CKD interaction on goals attainment showed female CKD subjects had lower non-HDL and TG goals attainment compared with non-CKD males (both p < 0.019). Conclusion: Although presenting with more comorbidities, the CKD population had suboptimal lipid goal attainment rate as compared with the non-CKD population. Further efforts may be required for better lipid control especially on the female CKD subjects. ? Ivyspring International Publisher. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84896737477&doi=10.7150%2fijms.7069&partnerID=40&md5=7098168b01bf5afbb188973f3e4d2cdd https://scholars.lib.ntu.edu.tw/handle/123456789/469774 |
ISSN: | 1449-1907 | DOI: | 10.7150/ijms.7069 | SDG/Keyword: | acetylsalicylic acid; acipimox; alpha adrenergic receptor blocking agent; angiotensin receptor antagonist; antilipemic agent; calcium channel blocking agent; cholesterol; clopidogrel; colestyramine; dipeptidyl carboxypeptidase inhibitor; diuretic agent; ezetimibe; fibric acid derivative; high density lipoprotein cholesterol; hydroxymethylglutaryl coenzyme A reductase inhibitor; low density lipoprotein cholesterol; triacylglycerol; aged; article; atherosclerosis; cerebrovascular accident; cholesterol blood level; chronic kidney disease; comorbidity; controlled study; disease control; drug use; dyslipidemia; female; glucose intolerance; goal attainment; heart failure; human; hypertension; major clinical study; male; sex; Taiwan; triacylglycerol blood level; atherosclerosis.; chronic kidney disease; goal; lipid; Atherosclerosis; Cross-Sectional Studies; Female; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Male; Multivariate Analysis; Renal Insufficiency, Chronic; Taiwan; Triglycerides |
Appears in Collections: | 醫學教育暨生醫倫理學科所 |
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