https://scholars.lib.ntu.edu.tw/handle/123456789/469775
標題: | Spatial repolarization heterogeneity detected by magnetocardiography correlates with cardiac iron overload and adverse cardiac events in beta-thalassemia major | 作者: | CHUN-AN CHEN MENG-YAO LU STEVEN SHINN-FORNG PENG Lin K.-H. HSIU-HAO CHANG YUNG-LI YANG SHIANN-TANG JOU Lin D.-T. YEN BIN LIU Horng H.-E. Yang H.-C. JOU-KOU WANG MEI-HWAN WU CHAU-CHUNG WU |
公開日期: | 2014 | 出版社: | Public Library of Science | 卷: | 9 | 期: | 1 | 來源出版物: | PLoS ONE | 摘要: | Background: Patients with transfusion-dependent beta-thalassemia major (TM) are at risk for myocardial iron overload and cardiac complications. Spatial repolarization heterogeneity is known to be elevated in patients with certain cardiac diseases, but little is known in TM patients. The purpose of this study was to evaluate spatial repolarization heterogeneity in patients with TM, and to investigate the relationships between spatial repolarization heterogeneity, cardiac iron load, and adverse cardiac events. Methods and Results: Fifty patients with TM and 55 control subjects received 64-channel magnetocardiography (MCG) to determine spatial repolarization heterogeneity, which was evaluated by a smoothness index of QTc (SI-QTc), a standard deviation of QTc (SD-QTc), and a QTc dispersion. Left ventricular function and myocardial T2* values were assessed by cardiac magnetic resonance. Patients with TM had significantly greater SI-QT c, SD-QTc, and QTc dispersion compared to the control subjects (all p values<0.001). Spatial repolarization heterogeneity was even more pronounced in patients with significant iron overload (T2*<20 ms, n = 20) compared to those with normal T2*(all p values<0.001). Loge cardiac T2* correlated with SI-QT c (r = -0.609, p<0.001), SD-QTc (r = -0.572, p<0.001), and QTc dispersion (r = -0.622, p<0.001), while all these indices had no relationship with measurements of the left ventricular geometry or function. At the time of study, 10 patients had either heart failure or arrhythmia. All 3 indices of repolarization heterogeneity were related to the presence of adverse cardiac events, with areas under the receiver operating characteristic curves (ranged between 0.79 and 0.86), similar to that of cardiac T2*. Conclusions: Multichannel MCG demonstrated that patients with TM had increased spatial repolarization heterogeneity, which is related to myocardial iron load and adverse cardiac events. ? 2014 Chen et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899956265&doi=10.1371%2fjournal.pone.0086524&partnerID=40&md5=21dc0b9c4c60909dfe84e16917123ae6 https://scholars.lib.ntu.edu.tw/handle/123456789/469775 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0086524 | SDG/關鍵字: | adult; article; beta thalassemia; cardiac iron load; cardiovascular magnetic resonance; cardiovascular parameters; controlled study; correlation analysis; female; heart arrhythmia; heart disease; heart failure; heart left ventricle function; human; iron overload; magnetocardiography; major clinical study; male; QT interval; receiver operating characteristic; spatial repolarization heterogeneity; Taiwan; Adult; Area Under Curve; beta-Thalassemia; Female; Heart Conduction System; Heart Diseases; Humans; Iron Overload; Magnetocardiography; Male; Myocardium; Statistics, Nonparametric; Taiwan; Ventricular Function, Left |
顯示於: | 醫學教育暨生醫倫理學科所 |
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