https://scholars.lib.ntu.edu.tw/handle/123456789/469808
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Ueng, Kwo-Chang | en_US |
dc.contributor.author | Lin, Lung-Chun | en_US |
dc.contributor.author | Voon, Wen-Chol | en_US |
dc.contributor.author | Lin, Ming-Cheng | en_US |
dc.contributor.author | YEN BIN LIU | en_US |
dc.contributor.author | Su, Ho-Ming | en_US |
dc.contributor.author | PO-YUAN CHANG | en_US |
dc.contributor.author | Lin, Tsung-Hsien | en_US |
dc.contributor.author | Chen, Wei-Liang | en_US |
dc.contributor.author | CHAU-CHUNG WU | en_US |
dc.contributor.author | Lai, Wen-Ter | en_US |
dc.contributor.author | TSUNG-HSIEN LIN | en_US |
dc.creator | Ueng K.-C.;Lin L.-C.;Voon W.-C.;Lin M.-C.;Liu Y.-B.;Su H.-M.;Chang P.-Y.;Lin T.-H.;Chen W.-L.;Chau-Chung Wu;Lai W.-T.;Lin C.-S. | - |
dc.date.accessioned | 2020-03-04T09:03:19Z | - |
dc.date.available | 2020-03-04T09:03:19Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0803-7051 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-75449086084&doi=10.1080%2f08037050802102660&partnerID=40&md5=8aa95e65427dfc0cff7bf519c031dad0 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/469808 | - |
dc.description.abstract | Aims. This study sought to compare the antihypertensive efficacy and tolerability of a fixed-dose combination with amlodipine/benazepril with that of amlodipine monotherapy in Chinese hypertensive subjects. Results. This multicenter, double-blind, 8-week study randomized 111 patients to fixed-dose amlodipine besylate/benazepril HCl (2.5/5 mg/day titrated to 5/10 mg/day as needed at week 4 to reach goal blood pressure (BP) < 140/90 mmHg) or amlodipine besylate monotherapy (5 mg/day titrated to 10 mg/day as needed). At week 8, patients randomized to combination therapy compared with monotherapy had a comparable BP control rate (56.0% vs 46.2%; p = 0.32). Fixed-dose combination resulted in similar reductions in sitting systolic (SBP) and diastolic BP (DBP) compared with monotherapy (SBP: -19.3 ± 12.5 vs -20.9 ± 13.3 mmHg; DBP: -9.2 ± 10.4 vs -11.3 ± 9.3 mmHg; both p = NS). Safety profiles did not differ between groups, but cough was more common in the combination group (11.0% vs 0%; p = 0.013). Conclusions. In this group of patients, comparable antihypertensive effects were seen with the fixed-dose combination therapy, compared with amlodipine monotherapy. Both treatments appeared well tolerated in the studied population, but cough was more common in the fixed-dose combination group. | - |
dc.relation.ispartof | Blood Pressure | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | amlodipine besylate; amlodipine besylate plus benazepril; antihypertensive agent; amlodipine; antihypertensive agent; benazepril; benzazepine derivative; calcium channel blocking agent; dipeptidyl carboxypeptidase inhibitor; adult; aged; ankle edema; antihypertensive activity; article; blood pressure regulation; Chinese; clinical trial; combination chemotherapy; comparative study; controlled clinical trial; controlled study; coughing; diastolic blood pressure; disease severity; dizziness; double blind procedure; drug dose comparison; drug dose titration; drug efficacy; drug induced headache; drug safety; drug tolerability; female; heart palpitation; human; hypertension; hypotension; low drug dose; major clinical study; male; monotherapy; multicenter study; priority journal; randomized controlled trial; risk reduction; systolic blood pressure; therapy effect; drug combination; middle aged; Adult; Amlodipine; Benzazepines; Blood Pressure; China; Cough; Dose-Response Relationship, Drug; Double-Blind Method; Drug Toxicity; Female; Humans; Hypertension; Male; Middle Aged; Treatment Outcome; Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzazepines; Calcium Channel Blockers; Drug Combinations | - |
dc.title | An eight-week, multicenter, randomized, double-blind study to evaluate the efficacy and tolerability of fixed-dose amlodipine/benazepril combination in comparison with amlodipine as first-line therapy in Chinese patients with mild to moderate hypertension | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1080/08037050802102660 | - |
dc.identifier.pmid | 18649156 | - |
dc.identifier.scopus | 2-s2.0-75449086084 | - |
dc.relation.pages | 24-31 | - |
dc.relation.journalvolume | 17 | - |
dc.relation.journalissue | SUPPL. 1 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUHHC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Electronics Engineering | - |
crisitem.author.dept | Electrical Engineering | - |
crisitem.author.dept | MediaTek-NTU Research Center | - |
crisitem.author.orcid | 0000-0002-7325-0823 | - |
crisitem.author.orcid | 0000-0003-0623-9146 | - |
crisitem.author.orcid | 0000-0001-5536-0175 | - |
crisitem.author.orcid | 0000-0001-8191-475X | - |
crisitem.author.orcid | 0000-0002-1733-5945 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
顯示於: | 醫學教育暨生醫倫理學科所 |
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