https://scholars.lib.ntu.edu.tw/handle/123456789/470007
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | MENG-YAO LU | en_US |
dc.contributor.author | Liu Y.-L. | en_US |
dc.contributor.author | HSIU-HAO CHANG | en_US |
dc.contributor.author | SHIANN-TANG JOU | en_US |
dc.contributor.author | YUNG-LI YANG | en_US |
dc.contributor.author | Lin K.-H. | en_US |
dc.contributor.author | Lin D.-T. | en_US |
dc.contributor.author | Lee Y.-L. | en_US |
dc.contributor.author | Lee H. | en_US |
dc.contributor.author | Wu P.-Y. | en_US |
dc.contributor.author | Luo T.-Y. | en_US |
dc.contributor.author | Shen L.-H. | en_US |
dc.contributor.author | Huang S.-F. | en_US |
dc.contributor.author | Liao Y.-F. | en_US |
dc.contributor.author | WEN-MING HSU | en_US |
dc.contributor.author | KAI-YUAN TZEN | en_US |
dc.creator | Tzen K.-Y.;WEN-MING HSU;Liao Y.-F.;Huang S.-F.;Shen L.-H.;Luo T.-Y.;Wu P.-Y.;Lee H.;Lee Y.-L.;Lin D.-T.;Lin K.-H.;Yang Y.-L.;Jou S.-T.;Chang H.-H.;Liu Y.-L.;Lu M.-Y. | - |
dc.date.accessioned | 2020-03-05T03:20:19Z | - |
dc.date.available | 2020-03-05T03:20:19Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0161-5505 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872046559&doi=10.2967%2fjnumed.112.102772&partnerID=40&md5=36b45b2482a3b43e6234556fe9c52c6d | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/470007 | - |
dc.description.abstract | Neuroblastic tumors are childhood neoplasms that possess amino acid decarboxylase (AADC) activity and can theoretically be imaged by 18F-fluorodihydroxyphenylalanine (18F-FDOPA) PET, a new diagnostic tool for neuroendocrine tumors. In this study, we explored the accuracy and clinical role of 18F-FDOPA PET in neuroblastic tumors. Methods: From 2008 to 2011, patients with tissue-proven neuroblastic tumors receiving 18F-FDOPA PET at initial diagnosis or during follow-ups were enrolled. The sensitivity and specificity of 18F-FDOPA PET were compared with those of 123I-metaiodobenzylguanidine ( 123I-MIBG) scintigraphy and 18F-FDG PET, using tumor histology as the standard. The maximum standardized uptake value and tumor-to-liver uptake ratio on 18F-FDOPA PET were measured and correlated with AADC messenger RNA level in tumor tissue. Results: Fifty tumors from 34 patients, including 42 neuroblastic tumors and 8 lesions without viable tumor cells, were eligible for analysis. 18F-FDOPA PET successfully detected neuroblastic tumors of different histologic types in various anatomic sites, at a sensitivity of 97.6% (87.4%- 99.9%) and a specificity of 87.5% (47.3%-99.7%). In tumors with concomitant studies, 18F-FDOPA PET demonstrated a higher sensitivity than 123I-MIBG scintigraphy (n = 18; P = 0.0455) or 18F-FDG PET (n = 46; P = 0.0455). Among the 18 tumors with concomitant 123I- MIBG scans, 4 tumors with viable cells were 123I-MIBG-negative but were successfully detected by 18F-FDOPA PET. The tumor uptake of 18F-FDOPA significantly correlated with AADC expression (n 5 15 nonhepatic tumors; maximum standardized uptake value, P 5 0.0002; tumor-to-liver uptake ratio, P < 0.0001). Conclusion: 18F- FDOPA PET showed high sensitivity and specificity in detecting and tracking neuroblastic tumors in this preliminary study with a small cohort of patients and might be complementary to 123I-MIBG scintigraphy and 18F-FDG PET. By correlating with AADC expression, 18F-FDOPA PET might serve as a useful imaging tool for the functional assessment of neuroblastic tumors. COPYRIGHT ? 2013 by the Society of Nuclear Medicine and Molecular Imaging, Inc. | - |
dc.relation.ispartof | Journal of Nuclear Medicine | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | (3 iodobenzyl)guanidine i 123; 6 fluorodopa f 18; amino acid decarboxylase; catecholamine; fluorodeoxyglucose f 18; messenger RNA; accuracy; amino acid decarboxylase gene; article; catecholamine metabolism; cell viability; clinical article; diagnostic imaging; diagnostic test accuracy study; diagnostic value; drug excretion; drug uptake; false negative result; false positive result; female; follow up; ganglioneuroma; gene expression; histopathology; human; human tissue; image analysis; infant; male; neuroblastoma; positron emission tomography; priority journal; protein expression; scintigraphy; sensitivity and specificity; tumor cell; 3-Iodobenzylguanidine; Biological Transport; Carboxy-Lyases; Catecholamines; Dihydroxyphenylalanine; Female; Fluorodeoxyglucose F18; Gene Expression Regulation, Neoplastic; Humans; Infant; Male; Neuroblastoma; Positron-Emission Tomography; Retrospective Studies; Sensitivity and Specificity; Vanilmandelic Acid | - |
dc.title | Characterization of neuroblastic tumors using 18F-FDOPA PET | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.2967/jnumed.112.102772 | - |
dc.identifier.pmid | 23213196 | - |
dc.identifier.scopus | 2-s2.0-84872046559 | - |
dc.relation.pages | 42-49 | - |
dc.relation.journalvolume | 54 | - |
dc.relation.journalissue | 1 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.orcid | 0000-0003-4461-9967 | - |
crisitem.author.orcid | 0000-0003-1832-8509 | - |
crisitem.author.orcid | 0000-0003-1483-0403 | - |
crisitem.author.orcid | 0000-0002-3598-7218 | - |
crisitem.author.orcid | 0000-0002-5145-9538 | - |
crisitem.author.orcid | 0000-0002-5657-8579 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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