https://scholars.lib.ntu.edu.tw/handle/123456789/470036
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Kapoor A. | en_US |
dc.contributor.author | WEN-MING HSU | en_US |
dc.contributor.author | Wang B.-J. | en_US |
dc.contributor.author | Wu G.-H. | en_US |
dc.contributor.author | Lin T.-Y. | en_US |
dc.contributor.author | Lee S.-J. | en_US |
dc.contributor.author | Yen C.-T. | en_US |
dc.contributor.author | Liang S.-M. | en_US |
dc.contributor.author | Liao Y.-F. | en_US |
dc.creator | Kapoor A.;Wen-Ming Hsu;Wang B.-J.;Wu G.-H.;Lin T.-Y.;Lee S.-J.;Yen C.-T.;Liang S.-M.;Liao Y.-F. | - |
dc.date.accessioned | 2020-03-05T03:20:28Z | - |
dc.date.available | 2020-03-05T03:20:28Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-78650848737&doi=10.3233%2fJAD-2010-100531&partnerID=40&md5=93d941c015ab191301c5695629ae6bd7 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/470036 | - |
dc.description.abstract | Amyloidogenic processing of amyloid-β precursor protein (AβPP) is associated with cholesterol- and sphingolipid-rich lipid rafts. Caveolin-1, a raft-residing protein, has been implicated in the pathogenesis of Alzheimer's disease. To determine the role of caveolin-1 in governing γ-secretase- mediated AβPP proteolysis, cellular γ-secretase activity was assessed in response to alteration in caveolin-1 expression. We demonstrated that suppression of caveolin-1 expression by RNA interference resulted in a significant increase in γ-secretase-mediated proteolysis of AβPP, generation of amyloid-β, and cleavage of Notch. Overexpression of caveolin-1 attenuated γ-secretase-mediated proteolysis of AβPP and Notch, substantiating the negative regulation of γ-secretase by caveolin-1. Furthermore, we found that cells deficient in caveolin-1 exhibited significantly increased co-localization of γ-secretase with clathrin-coated non-caveolar endocytic vesicles, demonstrating that the partitioning of γ-secretase between caveolar and non-caveolar membranes can be modulated by caveolin-1. Our data also showed that JNK activation is essential for caveolin-1-mediated regulation of γ-secretase. Together, our results strongly suggest that caveolin-1 is an important regulator of γ-secretase activity. ? 2010 - IOS Press and the authors. All rights reserved. | - |
dc.publisher | IOS Press | - |
dc.relation.ispartof | Journal of Alzheimer's Disease | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | amyloid precursor protein; beta secretase; caveolin 1; gamma secretase; Janus kinase; Notch receptor; article; cell fractionation; clinical assessment; coated vesicle; down regulation; enzyme activity; enzyme regulation; human; human cell; intracellular signaling; priority journal; protein degradation; protein expression; protein localization; protein protein interaction; RNA interference | - |
dc.title | Caveolin-1 Regulates γ-Secretase-Mediated AβPP Processing by Modulating Spatial Distribution of γ-Secretase in Membrane | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.3233/JAD-2010-100531 | - |
dc.identifier.scopus | 2-s2.0-78650848737 | - |
dc.relation.pages | 423-442 | - |
dc.relation.journalvolume | 22 | - |
dc.relation.journalissue | 2 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.orcid | 0000-0002-5145-9538 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。