https://scholars.lib.ntu.edu.tw/handle/123456789/470188
Title: | Fractionated evaluation of immunohistochemical hormone receptor expression enhances prognostic prediction in breast cancer patients treated with tamoxifen as adjuvant therapy | Authors: | CHING-HUNG LIN HUANG-CHUN LIEN Hu F.-C. YEN-SHEN LU SUNG-HSIN KUO Wu L.-C. You S.-L. ANN-LII CHENG KING-JEN CHANG CHIUN-SHENG HUANG |
Issue Date: | 2010 | Journal Volume: | 11 | Journal Issue: | 1 | Start page/Pages: | 1-9 | Source: | Journal of Zhejiang University: Science B | Abstract: | Objective: To compare the prognostic prediction between dichotomized and fractionated evaluations of hormone receptor expressions. Methods: Patients with stages I-III breast cancers, who received adjuvant tamoxifen, were enrolled. The expression of estrogen receptor (ER) and progesterone receptor (PR) was evaluated by immunohistochemistry (IHC). A fractionated score (F score), the percentage of positive-staining nuclei (0=none, 1=1%-10%, 2=11%-30%, 3=31%-50%, 4=51%-70%, and 5=71%-100%), was assigned to each case. The dichotomized scoring method defines an F score >1 as positive. The prognostic values of both scores were compared by multiple Cox's proportional hazard models of disease-free survival (DFS) and overall survival (OS). Results: Four hundred and sixteen patients with a median follow-up of 78.0 months were included. F scores for ER and PR correlated directly with DFS and OS. Although both the dichotomized and fractionated ER and PR scores were significantly associated with DFS and OS in univariate analyses, only fractionated ER and PR scores remained as independent prognostic factors of DFS and OS in the final multiple Cox's proportional hazard models. Conclusion: Fractionated IHC hormone receptor expression evaluation enhances the prognostic prediction compared with a dichotomized assessment. ? 2010 Zhejiang University and Springer Berlin Heidelberg. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-75949126959&doi=10.1631%2fjzus.B0900295&partnerID=40&md5=11ea053980a5073dd3aefb9278713847 https://scholars.lib.ntu.edu.tw/handle/123456789/470188 |
ISSN: | 1673-1581 | DOI: | 10.1631/jzus.B0900295 | SDG/Keyword: | estrogen receptor; progesterone receptor; tamoxifen; adjuvant therapy; adult; aged; animal tissue; article; breast cancer; cancer adjuvant therapy; cancer staging; controlled study; disease free survival; female; human; immunohistochemistry; major clinical study; nonhuman; overall survival; prediction; priority journal; prognosis; protein expression; scoring system; Adult; Aged; Aged, 80 and over; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Gene Expression Regulation; Humans; Immunohistochemistry; Middle Aged; Prognosis; Proportional Hazards Models; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen |
Appears in Collections: | 病理學科所 |
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