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  1. NTU Scholars
  2. 醫學院
  3. 病理學科所
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/470379
Title: Molecular subtypes of breast cancer emerging in young women in Taiwan: Evidence for more than just westernization as a reason for the disease in Asia
Authors: CHING-HUNG LIN 
JAU-YU LIAU 
YEN-SHEN LU 
CHIUN-SHENG HUANG 
Lee W.-C.
KUAN-TING KUO 
Ying-Chun Shen 
SUNG-HSIN KUO 
Lan C.
Liu J.M.
WEN-HUNG KUO 
KING-JEN CHANG 
ANN-LII CHENG 
Issue Date: 2009
Journal Volume: 18
Journal Issue: 6
Start page/Pages: 1807-1814
Source: Cancer Epidemiology Biomarkers and Prevention
Abstract: 
Background: In the past two decades, the incidence of breast cancer in young Taiwanese females has been rapidly increasing, approaching the risk level of western countries. As a first step to investigate the possible etiology, we examined the molecular subtypes of female breast cancer in Taiwan. Methods: This study included 1,028 consecutive patients with breast cancer diagnosed in National Taiwan University Hospital between 2004 and 2006. Estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2, cytokeratin 5/6, and epidermal growth factor receptor expression and/or gene amplification were analyzed. Results: Younger (?50 years) breast cancer patients had a higher prevalence of luminal A (67% versus 57%; P < 0.001) and a lower prevalence of basal-like subtype (9% versus 17%; P < 0.001) compared with older (>50 years) patients. The higher prevalence of luminal A subtype was mainly attributed to a higher ER (75% versus 63%; P < 0.001) and PR (47% versus 33%; P < 0.001) expression rate in younger patients than older patients. Tumors with histologic grade 3 were less prevalent in younger patients than in older patients (23% versus 30%; P = 0.01). For very young (<35 years) patients, the molecular subtype distribution, ER and/or PR expression rate, and histologic grade were not significantly different from those of less young (35-50 years) patients. Conclusions: Young breast cancer patients in Taiwan are characterized by a high prevalence of luminal A subtype and low prevalence of histologic grade 3 tumor and/or basal-like subtype. These features are distinct from young breast cancer patients in western countries. Copyright ? 2009 American Association for Cancer Research.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-67449085161&doi=10.1158%2f1055-9965.EPI-09-0096&partnerID=40&md5=643711e3689a9aa9be717fba7041cdd9
https://scholars.lib.ntu.edu.tw/handle/123456789/470379
ISSN: 1055-9965
DOI: 10.1158/1055-9965.EPI-09-0096
SDG/Keyword: cytokeratin 5; cytokeratin 6; epidermal growth factor receptor; epidermal growth factor receptor 2; estrogen receptor; progesterone receptor; adult; aged; article; Asia; breast cancer; cancer classification; cancer grading; cancer risk; controlled study; evidence based practice; female; gene amplification; human; immunohistochemistry; major clinical study; prevalence; priority journal; Taiwan; Age Distribution; Age Factors; Breast Neoplasms; Female; Gene Expression; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Incidence; Keratin-5; Keratin-6; Neoplasm Staging; Receptor, Epidermal Growth Factor; Receptor, erbB-2; Receptors, Estrogen; Receptors, Progesterone; Taiwan; Tumor Markers, Biological
[SDGs]SDG3
Appears in Collections:病理學科所

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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