https://scholars.lib.ntu.edu.tw/handle/123456789/470379
Title: | Molecular subtypes of breast cancer emerging in young women in Taiwan: Evidence for more than just westernization as a reason for the disease in Asia | Authors: | CHING-HUNG LIN JAU-YU LIAU YEN-SHEN LU CHIUN-SHENG HUANG Lee W.-C. KUAN-TING KUO Ying-Chun Shen SUNG-HSIN KUO Lan C. Liu J.M. WEN-HUNG KUO KING-JEN CHANG ANN-LII CHENG |
Issue Date: | 2009 | Journal Volume: | 18 | Journal Issue: | 6 | Start page/Pages: | 1807-1814 | Source: | Cancer Epidemiology Biomarkers and Prevention | Abstract: | Background: In the past two decades, the incidence of breast cancer in young Taiwanese females has been rapidly increasing, approaching the risk level of western countries. As a first step to investigate the possible etiology, we examined the molecular subtypes of female breast cancer in Taiwan. Methods: This study included 1,028 consecutive patients with breast cancer diagnosed in National Taiwan University Hospital between 2004 and 2006. Estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2, cytokeratin 5/6, and epidermal growth factor receptor expression and/or gene amplification were analyzed. Results: Younger (?50 years) breast cancer patients had a higher prevalence of luminal A (67% versus 57%; P < 0.001) and a lower prevalence of basal-like subtype (9% versus 17%; P < 0.001) compared with older (>50 years) patients. The higher prevalence of luminal A subtype was mainly attributed to a higher ER (75% versus 63%; P < 0.001) and PR (47% versus 33%; P < 0.001) expression rate in younger patients than older patients. Tumors with histologic grade 3 were less prevalent in younger patients than in older patients (23% versus 30%; P = 0.01). For very young (<35 years) patients, the molecular subtype distribution, ER and/or PR expression rate, and histologic grade were not significantly different from those of less young (35-50 years) patients. Conclusions: Young breast cancer patients in Taiwan are characterized by a high prevalence of luminal A subtype and low prevalence of histologic grade 3 tumor and/or basal-like subtype. These features are distinct from young breast cancer patients in western countries. Copyright ? 2009 American Association for Cancer Research. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-67449085161&doi=10.1158%2f1055-9965.EPI-09-0096&partnerID=40&md5=643711e3689a9aa9be717fba7041cdd9 https://scholars.lib.ntu.edu.tw/handle/123456789/470379 |
ISSN: | 1055-9965 | DOI: | 10.1158/1055-9965.EPI-09-0096 | SDG/Keyword: | cytokeratin 5; cytokeratin 6; epidermal growth factor receptor; epidermal growth factor receptor 2; estrogen receptor; progesterone receptor; adult; aged; article; Asia; breast cancer; cancer classification; cancer grading; cancer risk; controlled study; evidence based practice; female; gene amplification; human; immunohistochemistry; major clinical study; prevalence; priority journal; Taiwan; Age Distribution; Age Factors; Breast Neoplasms; Female; Gene Expression; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Incidence; Keratin-5; Keratin-6; Neoplasm Staging; Receptor, Epidermal Growth Factor; Receptor, erbB-2; Receptors, Estrogen; Receptors, Progesterone; Taiwan; Tumor Markers, Biological |
Appears in Collections: | 病理學科所 |
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