https://scholars.lib.ntu.edu.tw/handle/123456789/470379
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHING-HUNG LIN | en_US |
dc.contributor.author | JAU-YU LIAU | en_US |
dc.contributor.author | YEN-SHEN LU | en_US |
dc.contributor.author | CHIUN-SHENG HUANG | en_US |
dc.contributor.author | Lee W.-C. | en_US |
dc.contributor.author | KUAN-TING KUO | en_US |
dc.contributor.author | Ying-Chun Shen | en_US |
dc.contributor.author | SUNG-HSIN KUO | en_US |
dc.contributor.author | Lan C. | en_US |
dc.contributor.author | Liu J.M. | en_US |
dc.contributor.author | WEN-HUNG KUO | en_US |
dc.contributor.author | KING-JEN CHANG | en_US |
dc.contributor.author | ANN-LII CHENG | en_US |
dc.creator | Lin C.-H.;Jau-Yu Liau;Lu Y.-S.;Huang C.-S.;Lee W.-C.;Kuo K.-T.;Shen Y.-C.;Kuo S.-H.;Lan C.;Liu J.M.;Kuo W.-H.;Chang K.-J.;Cheng A.-L. | - |
dc.date.accessioned | 2020-03-05T06:28:45Z | - |
dc.date.available | 2020-03-05T06:28:45Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1055-9965 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-67449085161&doi=10.1158%2f1055-9965.EPI-09-0096&partnerID=40&md5=643711e3689a9aa9be717fba7041cdd9 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/470379 | - |
dc.description.abstract | Background: In the past two decades, the incidence of breast cancer in young Taiwanese females has been rapidly increasing, approaching the risk level of western countries. As a first step to investigate the possible etiology, we examined the molecular subtypes of female breast cancer in Taiwan. Methods: This study included 1,028 consecutive patients with breast cancer diagnosed in National Taiwan University Hospital between 2004 and 2006. Estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2, cytokeratin 5/6, and epidermal growth factor receptor expression and/or gene amplification were analyzed. Results: Younger (?50 years) breast cancer patients had a higher prevalence of luminal A (67% versus 57%; P < 0.001) and a lower prevalence of basal-like subtype (9% versus 17%; P < 0.001) compared with older (>50 years) patients. The higher prevalence of luminal A subtype was mainly attributed to a higher ER (75% versus 63%; P < 0.001) and PR (47% versus 33%; P < 0.001) expression rate in younger patients than older patients. Tumors with histologic grade 3 were less prevalent in younger patients than in older patients (23% versus 30%; P = 0.01). For very young (<35 years) patients, the molecular subtype distribution, ER and/or PR expression rate, and histologic grade were not significantly different from those of less young (35-50 years) patients. Conclusions: Young breast cancer patients in Taiwan are characterized by a high prevalence of luminal A subtype and low prevalence of histologic grade 3 tumor and/or basal-like subtype. These features are distinct from young breast cancer patients in western countries. Copyright ? 2009 American Association for Cancer Research. | - |
dc.relation.ispartof | Cancer Epidemiology Biomarkers and Prevention | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | cytokeratin 5; cytokeratin 6; epidermal growth factor receptor; epidermal growth factor receptor 2; estrogen receptor; progesterone receptor; adult; aged; article; Asia; breast cancer; cancer classification; cancer grading; cancer risk; controlled study; evidence based practice; female; gene amplification; human; immunohistochemistry; major clinical study; prevalence; priority journal; Taiwan; Age Distribution; Age Factors; Breast Neoplasms; Female; Gene Expression; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Incidence; Keratin-5; Keratin-6; Neoplasm Staging; Receptor, Epidermal Growth Factor; Receptor, erbB-2; Receptors, Estrogen; Receptors, Progesterone; Taiwan; Tumor Markers, Biological | - |
dc.title | Molecular subtypes of breast cancer emerging in young women in Taiwan: Evidence for more than just westernization as a reason for the disease in Asia | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1158/1055-9965.EPI-09-0096 | - |
dc.identifier.pmid | 19505913 | - |
dc.identifier.scopus | 2-s2.0-67449085161 | - |
dc.relation.pages | 1807-1814 | - |
dc.relation.journalvolume | 18 | - |
dc.relation.journalissue | 6 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Medical Oncology-NTUCC | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.dept | Clinical Trial Center | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Radiation Oncology-NTUCC | - |
crisitem.author.dept | Division of Radiation Oncology | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.orcid | 0000-0003-2403-4056 | - |
crisitem.author.orcid | 0000-0002-1336-3850 | - |
crisitem.author.orcid | 0000-0001-7461-1291 | - |
crisitem.author.orcid | 0000-0002-6557-211X | - |
crisitem.author.orcid | 0000-0002-3657-1652 | - |
crisitem.author.orcid | 0000-0003-0054-887X | - |
crisitem.author.orcid | 0000-0002-9881-4605 | - |
crisitem.author.orcid | 0000-0001-9811-3422 | - |
crisitem.author.orcid | 0000-0002-9152-6512 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | Oncology-NTUH | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 病理學科所 |
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