https://scholars.lib.ntu.edu.tw/handle/123456789/470470
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | JIA-HUEI TSAI | en_US |
dc.contributor.author | Rabinovitch P.S. | en_US |
dc.contributor.author | Huang D. | en_US |
dc.contributor.author | Small T. | en_US |
dc.contributor.author | Mattis A.N. | en_US |
dc.contributor.author | Kakar S. | en_US |
dc.contributor.author | Choi W.-T. | en_US |
dc.creator | Jia-Huei Tsai;Rabinovitch P.S.;Huang D.;Small T.;Mattis A.N.;Kakar S.;Choi W.-T. | - |
dc.date.accessioned | 2020-03-05T07:31:43Z | - |
dc.date.available | 2020-03-05T07:31:43Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0016-5085 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032933675&doi=10.1053%2fj.gastro.2017.08.031&partnerID=40&md5=fd5598937c5f109a498ca76229ce490f | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/470470 | - |
dc.description.abstract | There is controversy over how to best manage patients with inflammatory bowel disease and flat low-grade dysplasia (fLGD) in the colon. We performed a retrospective analysis of formalin-fixed paraffin-embedded colon tissues with fLGD from 37 patients undergoing surveillance colonoscopy for inflammatory bowel disease from 1990 to 2015 at the University of California at San Francisco Medical Center, to determine whether detection of aneuploidy is associated with later development of high-grade dysplasia (HGD) or colorectal cancer. Medical data were collected from the patients for a mean follow-up time of 37 months. Using flow cytometry analysis of paraffin-embedded colon tissue, we detected aneuploidy in 15 of 37 samples with fLGD (40.5%). By comparison, aneuploidy was detected in 14 of 15 samples with flat HGD (93.3%) and 2 of 45 samples that were negative for dysplasia (4.4%). The univariate hazard ratio for subsequent detection of HGD or colorectal cancer in patients with fLGD and aneuploidy was 5.3 (95% CI, 1.542?24.121) within a mean follow-up time of 37 months. The presence of aneuploidy therefore identifies patients with fLGD in colon tissue who have an increased risk for HGD or colorectal cancer and may provide supportive evidence to a morphologic impression or suspicion of flat HGD. ? 2017 AGA Institute | - |
dc.publisher | W.B. Saunders | - |
dc.relation.ispartof | Gastroenterology | - |
dc.subject | Colon Cancer Risk Factor; Early Detection; IBD; Marker | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | adult; aneuploidy; Article; clinical article; colon tissue; colonoscopy; colorectal cancer; dysplasia; female; flat low grade dysplasia; flow cytometry; follow up; high grade dysplasia; human; human tissue; inflammatory bowel disease; male; outcome assessment; priority journal; retrospective study; risk assessment; California; cancer grading; cell transformation; colon; colon resection; colorectal tumor; complication; Crohn disease; disease exacerbation; early cancer diagnosis; genetics; middle aged; pathology; predictive value; prognosis; risk factor; time factor; ulcerative colitis; university hospital; Academic Medical Centers; Aneuploidy; Cell Transformation, Neoplastic; Colectomy; Colitis, Ulcerative; Colon; Colorectal Neoplasms; Crohn Disease; Disease Progression; Early Detection of Cancer; Female; Flow Cytometry; Humans; Male; Middle Aged; Neoplasm Grading; Predictive Value of Tests; Prognosis; Retrospective Studies; Risk Assessment; Risk Factors; San Francisco; Time Factors | - |
dc.title | Association of Aneuploidy and Flat Dysplasia With Development of High-Grade Dysplasia or Colorectal Cancer in Patients With Inflammatory Bowel Disease | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1053/j.gastro.2017.08.031 | - |
dc.identifier.pmid | 28843957 | - |
dc.identifier.scopus | 2-s2.0-85032933675 | - |
dc.relation.pages | 1492-14950000 | - |
dc.relation.journalvolume | 153 | - |
dc.relation.journalissue | 6 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.orcid | 0000-0002-9620-0431 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 病理學科所 |
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