https://scholars.lib.ntu.edu.tw/handle/123456789/470798
標題: | Precancerous esophageal epithelia are associated with significantly increased scattering coefficients | 作者: | Su J.-W. Lin Y.-H. CHUN-PIN CHIANG JANG-MING LEE Hsieh C.-M. MIN-SHU HSIEH Yang P.-W. Wang C.-P. PING-HUEI TSENG YI-CHIA LEE Sung K.-B. |
公開日期: | 2015 | 出版社: | OSA - The Optical Society | 卷: | 6 | 期: | 10 | 起(迄)頁: | 3795-3805 | 來源出版物: | Biomedical Optics Express | 摘要: | The progression of epithelial precancers into cancer is accompanied by changes of tissue and cellular structures in the epithelium. Correlations between the structural changes and scattering coefficients of esophageal epithelia were investigated using quantitative phase images and the scattering-phase theorem. An ex vivo study of 14 patients demonstrated that the average scattering coefficient of precancerous epithelia was 37.8% higher than that of normal epithelia from the same patient. The scattering coefficients were highly correlated with morphological features including the cell density and the nuclear-to-cytoplasmic ratio. A high interpatient variability in scattering coefficients was observed and suggests identifying precancerous lesions based on the relative change in scattering coefficients. ? 2015 Optical Society of America. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84948773429&doi=10.1364%2fBOE.6.003795&partnerID=40&md5=58b088583ef12c051eba1336a29ee209 https://scholars.lib.ntu.edu.tw/handle/123456789/470798 |
ISSN: | 2156-7085 | DOI: | 10.1364/BOE.6.003795 | SDG/關鍵字: | Cell density; Cellular structure; Ex-vivo; Highly-correlated; Morphological features; Nuclear-to-cytoplasmic ratios; Phase image; Scattering co-efficient; Optical constants; anisotropy; Article; cell density; controlled study; correlation analysis; electron tomography; esophagus mucosa; histology; human; human tissue; image analysis; light related phenomena; precancer; scattering coefficient; scattering phase theorem; statistical analysis; validation study |
顯示於: | 病理學科所 |
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