https://scholars.lib.ntu.edu.tw/handle/123456789/470801
標題: | Mixed lung mucoepidermoid carcinoma and adenocarcinoma with identical mutations in an epidermal growth factor receptor gene | 作者: | Jhuang J.-Y. Chou Y.-H. Hua S.-F. MIN-SHU HSIEH |
公開日期: | 2014 | 出版社: | Elsevier USA | 卷: | 98 | 期: | 2 | 起(迄)頁: | 695-697 | 來源出版物: | Annals of Thoracic Surgery | 摘要: | Lung cancers presenting two different histologic types are relatively rare. This paper presents a case report of mixed lung cancer comprising mucoepidermoid carcinoma and conventional adenocarcinoma, a combination that has not been reported previously. These two carcinomas showed distinct morphologic and immunohistochemical features. However, gene analysis revealed identical mutations in each component, which indicates they possess a monoclonal origin. Specifically, we identified the same mutation in exon 19 of the epidermal growth factor receptor gene. Molecular analysis further substantiated a monoclonal origin with divergent differentiation, as opposed to the collision of discrete tumors. ? 2014 by The Society of Thoracic Surgeons Published by Elsevier Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84905447391&doi=10.1016%2fj.athoracsur.2013.10.035&partnerID=40&md5=c32c0aaeda197f49306e61dffdab2d39 https://scholars.lib.ntu.edu.tw/handle/123456789/470801 |
ISSN: | 0003-4975 | DOI: | 10.1016/j.athoracsur.2013.10.035 | SDG/關鍵字: | epidermal growth factor receptor; thyroid transcription factor 1; adenosquamous carcinoma; adult; article; case report; computer assisted tomography; female; gene mutation; human; human tissue; immunoreactivity; lung adenocarcinoma; middle aged; mixed tumor; priority journal; thorax radiography; transbronchial biopsy; tumor biopsy; Adenocarcinoma; Carcinoma, Mucoepidermoid; Female; Humans; Lung Neoplasms; Middle Aged; Mutation; Neoplasms, Multiple Primary; Receptor, Epidermal Growth Factor |
顯示於: | 病理學科所 |
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