https://scholars.lib.ntu.edu.tw/handle/123456789/470818
標題: | Intravascular Large B cell Lymphoma in Taiwan: An Asian Variant of Non-germinal-center Origin | 作者: | MIN-SHU HSIEH Yeh Y.-C. Chou Y.-H. CHUNG-WU LIN |
公開日期: | 2010 | 卷: | 109 | 期: | 3 | 起(迄)頁: | 185-191 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: Intravascular large B cell lymphoma (IVLBCL) is a rare variant of diffuse large B cell lymphoma. We reported the clinical and immunohistochemical characteristics of 10 cases of IVLBCL from Taiwan between 1995 and 2008. Methods: Clinical data were reviewed and immunoperoxidase stains were performed with antibodies against CD20, CD10, Bcl-6, MUM1, and CD5. Results: There were eight males and two females with a median age of 59 years. Patients presented with dyspnea (5/10), fever (7/10), splenomegaly (5/10), and bone marrow involvement (8/10). Anemia (9/10), thrombocytopenia (6/10), and elevated serum lactate dehydrogenase or ferritin levels (8/10) were also common. Nine cases were CD20+CD10-Bcl-6-, similar to non-germinal center B cells. Six out of seven patients survived after chemotherapy, but three cases with thrombocytopenia that precluded chemotherapy died within 2 months. Conclusion: Our cases of IVLBCL had a non-germinal center B origin and belonged to the Asian variant of this disease. The liver, spleen, and bone marrow, but rarely the skin or brain, were involved. Thrombocytopenia is a major risk factor for mortality in these cases. ? 2010 Formosan Medical Association & Elsevier. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77952102492&doi=10.1016%2fS0929-6646%2810%2960041-1&partnerID=40&md5=59539a49a932d89c4988219382b1099c https://scholars.lib.ntu.edu.tw/handle/123456789/470818 |
ISSN: | 0929-6646 | DOI: | 10.1016/S0929-6646(10)60041-1 | SDG/關鍵字: | CD20 antigen; CD5 antigen; common acute lymphoblastic leukemia antigen; ferritin; interferon regulatory factor 4; lactate dehydrogenase; protein bcl 6; adult; aged; anemia; article; B cell lymphoma; cancer diagnosis; cancer localization; cancer mortality; clinical article; clinical examination; dyspnea; female; ferritin blood level; fever; human; human tissue; immunohistochemistry; immunoperoxidase staining; lactate dehydrogenase blood level; male; risk factor; splenomegaly; Taiwan; thrombocytopenia; vascular tumor; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Asian Continental Ancestry Group; Female; Humans; Immunohistochemistry; Lymphoma, B-Cell; Male; Middle Aged; Survival Analysis; Taiwan; Thrombocytopenia; Treatment Outcome; Tumor Markers, Biological; Vascular Neoplasms |
顯示於: | 病理學科所 |
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