https://scholars.lib.ntu.edu.tw/handle/123456789/470915
標題: | The relationship between serum fibrosis markers and restrictive ventricular filling in patients with heart failure with reduced ejection fraction: A technetium-99m radionuclide ventriculography study | 作者: | Yen-Tin Lin YEN-HUNG LIN Xue-Ming Wu CHI-LUN KO RUOH-FANG YEN YING-HSIEN CHEN RON-BIN HSU CHII-MING LEE SHOEI-SHEN WANG MING-FONG CHEN YEN-WEN WU |
關鍵字: | fibrosis; restrictive filling; ventriculography. | 公開日期: | 10-一月-2017 | 出版社: | Impact Journals LLC | 卷: | 8 | 期: | 2 | 起(迄)頁: | 2381 | 來源出版物: | Oncotarget | 摘要: | Myocardial fibrosis leads to a restrictive diastolic filling pattern of the left ventricle which is associated with a poor prognosis in patients with heart failure. We investigated the relationship between cardiac fibrosis and restrictive filling pattern of the left ventricle measured by Tc99m left ventriculography in patients with chronic symptomatic heart failure. Serum cardiac extracellular matrix markers including type I and III aminoterminal propeptide of procollagen (PINP and PIIINP), matrix metalloproteinase-2,9 (MMP-2,9), and tissue inhibitor of MMP-1 (TIMP-1) were analyzed. Fifty-one (39 males) patients were enrolled. Their median age was 51.8 years, and median left ventricular ejection fraction was 31.9%. Time to peak filling rate of the left ventricle was significantly correlated with serum levels of the three cardiac extracellular matrix markers (TIMP-1, PIIINP, and MMP-2). The patients with a restrictive diastolic filling pattern of the left ventricle (time to peak filling rate ≤ 154 ms) had significantly higher levels of these extracellular matrix markers. In receiver operating characteristic curve analysis, areas under the curve of PIIINP, TIMP-1, and MMP-2 were 0.758, 0.695, and 0.751 to predict the presence of a restrictive pattern. In C-statistics, all three cardiac extracellular matrix markers significantly increased the area under the curve after adding creatinine. In net reclassification improvement and integrated discrimination improvement models, PIIINP and MMP-2 significantly improved the predictive power of age, creatinine and brain natriuretic peptide. In conclusion, serum extracellular matrix markers are significantly correlated with restrictive diastolic filling pattern of the left ventricle in patients with heart failure. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009782231&doi=10.18632%2foncotarget.13795&partnerID=40&md5=d38f6023550d5dfb202492bd9c49ef42 https://scholars.lib.ntu.edu.tw/handle/123456789/470915 https://pubmed.ncbi.nlm.nih.gov/27924061/ |
ISSN: | 1949-2553 | DOI: | 10.18632/oncotarget.13795 |
顯示於: | 醫學系 |
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