Skip navigation
  • 中文
  • English

DSpace CRIS

  • DSpace logo
  • Home
  • Organizations
  • Researchers
  • Research Outputs
  • Explore by
    • Organizations
    • Researchers
    • Research Outputs
  • Academic & Publications
  • Sign in
  • 中文
  • English
  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/470988
Title: Twenty-four year single-center experience of hepatitis B virus infection in heart transplantation
Authors: Chen Y.C.
Chuang M.K.
Chou N.K.
Chi N.H.
Wu I.H.
Chen Y.S.
Yu H.Y.
Huang S.C.
Wang C.H.
Tsao C.I.
Ko W.J.
SHOEI-SHEN WANG 
Issue Date: 2012
Journal Volume: 44
Journal Issue: 4
Start page/Pages: 910-912
Source: Transplantation Proceedings
Abstract: 
Objective: Hepatitis B virus (HBV) infection is hyperendemic in Taiwan. We have reported the outcome of (1) recipients with hepatitis B surface antigen (HBsAg)-positive; HBsAg-negative recipients who receive donor hearts from HBsAg-positive donors; and treatment with lamivudine of hepatitis B flare-ups after heart transplantation, using case numbers that range from 100 to 200. Methods: From July 1987 to May 2011, all 412 orthotopic heart transplant recipients and donors underwent routine preoperative screening for hepatitis B virus markers and liver function parameters. Lamivudine was prescribed prophylactically for recipients with elevated serum enzyme levels or an HBV DNA virus load before transplantation, or when there was evidence of hepatitis B flare-up after transplantation. Postoperative HBV markers and liver function parameters were collected over a mean follow-up time of 7.8 years. Results: Thirty-four recipients were HBsAg-positive before heart transplantation, and 23 experiencing HBV reactivation upon follow-up requiring lamivudine treatment. Clinical responses were achieved in all of them: 15 were complete and two, slow partial responses. Twenty-six recipients with an HBV na?ve status at the time of heart transplantation, and three patients received donor hearts from an HBsAg-positive donor under perioperative hepatitis B immunoglobulin prophylaxis. HBV infection was successfully prevented in two patients, but the other one contracted HBV hepatitis, which was successfully treated with lamivudine. Conclusions: HBV reactivation after the heart transplantation was common but usually well controlled with lamivudine treatment. Although posttransplantation liver function deteriorated for a period, there was no HBV infection-related morbidity or mortality. Perioperative hepatitis B immunoglobulin prophylaxis can successfully prevent HBV na?ve recipients from infection in some cases, but HBsAg-positive donors should only be considered in high risk situations. ? 2012 Elsevier Inc.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84860780069&doi=10.1016%2fj.transproceed.2012.03.040&partnerID=40&md5=8bf2570f7f97f8a5f03fd4349f5591cc
https://scholars.lib.ntu.edu.tw/handle/123456789/470988
ISSN: 0041-1345
DOI: 10.1016/j.transproceed.2012.03.040
metadata.dc.subject.other: hepatitis B antibody; hepatitis B surface antigen; lamivudine; virus DNA; adult; conference paper; controlled study; disease marker; donor; female; follow up; health center; heart transplantation; hepatitis B; high risk patient; human; liver function; major clinical study; male; morbidity; mortality; nonhuman; outcome assessment; postoperative infection; preoperative evaluation; priority journal; treatment response; virus load; virus reactivation; Adult; Alanine Transaminase; Antiviral Agents; Biological Markers; DNA, Viral; Donor Selection; Female; Heart Failure; Heart Transplantation; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins; Immunosuppressive Agents; Lamivudine; Male; Middle Aged; Retrospective Studies; Taiwan; Time Factors; Treatment Outcome; Viral Load; Virus Activation; Young Adult
[SDGs]SDG3
Appears in Collections:醫學系

Show full item record

SCOPUSTM   
Citations

12
checked on Aug 11, 2022

WEB OF SCIENCETM
Citations

14
checked on Aug 14, 2022

Page view(s)

3
checked on Aug 13, 2022

Google ScholarTM

Check

Altmetric

Altmetric

Related Items in TAIR


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Sherpa Romeo網站查詢,以確認出版單位之版權政策。
    Please use Sherpa Romeo to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)
Build with DSpace-CRIS - Extension maintained and optimized by Logo 4SCIENCE Feedback