https://scholars.lib.ntu.edu.tw/handle/123456789/470997
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Huang C.-L. | en_US |
dc.contributor.author | YEN-WEN WU | en_US |
dc.contributor.author | SHOEI-SHEN WANG | en_US |
dc.contributor.author | Tseng C.-D. | en_US |
dc.contributor.author | FU-TIEN CHIANG | en_US |
dc.contributor.author | Hsu K.-L. | en_US |
dc.contributor.author | CHII-MING LEE | en_US |
dc.contributor.author | KAI-YUAN TZEN | en_US |
dc.creator | Huang C.-L.;Wu Y.-W.;Shoei-Shen Wang;Tseng C.-D.;Chiang F.-T.;Hsu K.-L.;Lee C.-M.;Tzen K.-Y. | - |
dc.date.accessioned | 2020-03-05T08:37:51Z | - |
dc.date.available | 2020-03-05T08:37:51Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0914-7187 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-80052310465&doi=10.1007%2fs12149-011-0487-x&partnerID=40&md5=8e9d67d519e53b559028bb1122b0879f | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/470997 | - |
dc.description.abstract | Objective: Recent investigation has demonstrated that prostaglandin E 1 (PGE 1) therapy increased capillary density in explanted hearts. Dynamic 13N-ammonia positron emission tomography (PET) is reliable for non-invasive measurement of myocardial blood flow and myocardial perfusion reserve (MPR). The aim of this study was to investigate the effects of PGE 1 therapy during 4 weeks on reduction of myocardial perfusion abnormalities and increase of MPR in the patients with ischemic heart disease. Methods: In this double-blind, placebo-controlled trial, we randomly assigned 11 patients who had symptomatic heart failure and documented myocardial ischemia to 4 weeks intravenous infusion of PGE 1 (2.5 ng/kg/min; 8 patients, age 60 ± 13 years) or saline (3 patients, age 57 ± 13 years). Dynamic 13N-ammonia PET scans at rest and during adenosine stress were obtained at baseline and 12 weeks after treatment completion. Quantitative size/severity of perfusion defects and MPR change from baseline to follow-up PET were determined using a 17-segment model. Results: Compared with the control group, baseline MPR in the PGE 1 group was significantly lower (1.96 ± 0.78 vs. 2.71 ± 0.73; P < 0.001). MPR significantly improved 12 weeks after completion of PGE 1 infusion (1.96 ± 0.78 to 2.16 ± 0.77; P < 0.001). In contrast, MPR declined significantly in the placebo group (2.71 ± 0.73 to 2.01 ± 0.58, P < 0.001). Conclusion: Four weeks of PGE 1 infusion sustained MPR improvement in patients with ischemic heart disease. This may be an attractive therapeutic approach for no-option patients with severe ischemic cardiomyopathy. ? 2011 The Japanese Society of Nuclear Medicine. | - |
dc.relation.ispartof | Annals of Nuclear Medicine | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | ammonia n 13; dipyridamole tl 201; placebo; prostaglandin E1; radiopharmaceutical agent; unclassified drug; adult; aged; article; clinical article; continuous infusion; controlled study; disease severity; double blind procedure; female; follow up; heart failure; heart muscle ischemia; heart muscle perfusion; human; ischemic heart disease; low drug dose; male; pilot study; positron emission tomography; priority journal; quantitative analysis; randomized controlled trial; single photon emission computer tomography; treatment duration; Adult; Aged; Aged, 80 and over; Alprostadil; Ammonia; Cicatrix; Coronary Circulation; Female; Heart; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Ischemia; Pilot Projects; Positron-Emission Tomography; Prospective Studies | - |
dc.title | Continuous intravenous infusion of prostaglandin E1 improves myocardial perfusion reserve in patients with ischemic heart disease assessed by positron emission tomography: A pilot study | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1007/s12149-011-0487-x | - |
dc.identifier.pmid | 21461596 | - |
dc.identifier.scopus | 2-s2.0-80052310465 | - |
dc.relation.pages | 462-468 | - |
dc.relation.journalvolume | 25 | - |
dc.relation.journalissue | 7 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Nuclear Medicine-NTUH | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-1520-1166 | - |
crisitem.author.orcid | 0000-0003-3201-4143 | - |
crisitem.author.orcid | 0000-0003-4936-8968 | - |
crisitem.author.orcid | 0000-0002-1075-5787 | - |
crisitem.author.orcid | 0000-0002-5657-8579 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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