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  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/471000
Title: Preoperative proteinuria predicts adverse renal outcomes after coronary artery bypass grafting
Authors: Huang T.-M.
Wu V.-C.
Young G.-H.
Lin Y.-F.
Shiao C.-C.
Wu P.-C.
Li W.-Y.
Yu H.-Y.
Hu F.-C.
Lin J.-W.
Chen Y.-S.
Lin Y.-H.
SHOEI-SHEN WANG 
Hsu R.-B.
Chang F.-C.
Chou N.-K.
Chu T.-S.
Yeh Y.-C.
Tsai P.-R.
Huang J.-W.
Lin S.-L.
Chen Y.-M.
Ko W.-J.
Wu K.-D.
Issue Date: 2011
Journal Volume: 22
Journal Issue: 1
Start page/Pages: 156-163
Source: Journal of the American Society of Nephrology
Abstract: 
Whether preoperative proteinuria associates with adverse renal outcomes after cardiac surgery is unknown. Here, we performed a secondary analysis of a prospectively enrolled cohort of adult patients undergoing coronary artery bypass grafting (CABG) at a medical center and its two affiliate hospitals between 2003 and 2007. We excluded patients with stage 5 CKD or those who received dialysis previously. We defined proteinuria, measured with a dipstick, as mild (trace to 1+) or heavy (2+ to 4+). Among a total of 1052 patients, cardiac surgery-associated acute kidney injury (CSA-AKI) developed in 183 (17.4%) patients and required renal replacement therapy (RRT) in 50 (4.8%) patients. In a multiple logistic regression model, mild and heavy proteinuria each associated with an increased odds of CSA-AKI, independent of CKD stage and the presence of diabetes mellitus (mild: OR 1.66, 95% CI 1.09 to 2.52; heavy: OR 2.30, 95% CI 1.35 to 3.90). Heavy proteinuria also associated with increased odds of postoperative RRT (OR 7.29, 95% CI 3.00 to 17.73). In summary, these data suggest that preoperative proteinuria is a predictor of CSA-AKI among patients undergoing CABG. Copyright ? 2011 by the American Society of Nephrology.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-78651398215&doi=10.1681%2fASN.2010050553&partnerID=40&md5=b38aad81a9b860acfaba1b8ec94b5e2b
https://scholars.lib.ntu.edu.tw/handle/123456789/471000
ISSN: 1046-6673
DOI: 10.1681/ASN.2010050553
metadata.dc.subject.other: adrenalin; creatinine; dobutamine; dopamine; hemoglobin; isoprenaline; noradrenalin; acute kidney failure; adult; adverse outcome; anemia; article; cardiac surgery associated acute kidney injury; cardiopulmonary bypass; cerebrovascular accident; chronic kidney disease; chronic obstructive lung disease; comorbidity; congestive heart failure; coronary artery bypass graft; creatinine blood level; diabetes mellitus; dialysis; disease severity; female; heart infarction; heart left ventricle ejection fraction; heart surgery; hemodialysis patient; human; hypertension; major clinical study; male; meta analysis; peripheral occlusive artery disease; postoperative period; prediction; preoperative evaluation; priority journal; prospective study; proteinuria; renal replacement therapy; sensitivity analysis; Acute Kidney Injury; Aged; Cohort Studies; Coronary Artery Bypass; Female; Glomerular Filtration Rate; Humans; Kidney; Male; Middle Aged; Predictive Value of Tests; Preoperative Period; Prospective Studies; Proteinuria; Renal Replacement Therapy; Retrospective Studies; Risk Factors
[SDGs]SDG3
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