https://scholars.lib.ntu.edu.tw/handle/123456789/471015
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | YEN-HUNG LIN | en_US |
dc.contributor.author | Lin C. | en_US |
dc.contributor.author | Lo M.-T. | en_US |
dc.contributor.author | HUNG-JU LIN | en_US |
dc.contributor.author | YEN-WEN WU | en_US |
dc.contributor.author | RON-BIN HSU | en_US |
dc.contributor.author | CHIA-LUN CHAO | en_US |
dc.contributor.author | Hsu H.-C. | en_US |
dc.contributor.author | Wang P.-C. | en_US |
dc.contributor.author | VIN-CENT WU | en_US |
dc.contributor.author | SHOEI-SHEN WANG | en_US |
dc.contributor.author | CHII-MING LEE | en_US |
dc.contributor.author | KUO-LIONG CHIEN | en_US |
dc.contributor.author | YI-LWUN HO | en_US |
dc.contributor.author | MING-FONG CHEN | en_US |
dc.contributor.author | Peng C.-K. | en_US |
dc.creator | Lin Y.-H.;Lin C.;Lo M.-T.;Lin H.-J.;Wu Y.-W.;Hsu R.-B.;Chao C.-L.;Hsu H.-C.;Wang P.-C.;Wu V.-C.;Shoei-Shen Wang;Lee C.-M.;Chien K.-L.;Ho Y.-L.;Chen M.-F.;Peng C.-K. | - |
dc.date.accessioned | 2020-03-05T08:37:54Z | - |
dc.date.available | 2020-03-05T08:37:54Z | - |
dc.date.issued | 2010-12 | - |
dc.identifier.issn | 1434-6621 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79251510542&doi=10.1515%2fCCLM.2010.348&partnerID=40&md5=12ce4454f5ca3b2d37a6491ff074054b | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/471015 | - |
dc.description.abstract | Background: Cardiac extra-cellular matrix (ECM) fibrosis plays an important role in the pathophysiology of heart failure (HF). It may provide electrical heterogeneity and a substrate for arrhythmogenicity, which may cause sudden cardiac death (SCD). Methods: Twenty-one patients with manifestations of HF and a left ventricular ejection fraction (LVEF) ?50% were enrolled. The median age was 62 years and median LVEF was 33%. Time- and frequency-domain analysis of heart rate variability (HRV) on 24 h ambulatory electrocardiography recording was assessed. Serum markers of ECM turnover including type I and III aminoterminal propeptide of procollagen (PINP and PIIINP), matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) were analyzed. Results: The serum PIIINP concentration was correlated significantly with standard deviation of all normal to normal R-R intervals (SDNN) (r=-0.722, p=<0.001), percentage of adjacent NN interval differences >50 ms (pNN50) (r=-0.528, p=0.014), percentage of adjacent NN interval differences >20 ms (pNN20) (r=-0.545, p=0.002), very low frequency (VLF) (r=-0.490, p=0.024), low frequency (LF) (r=-0.491, p=0.024), and high frequency (HF) (r=-0.513, p=0.018). PINP, MMP-2, -9, TIMP-1 were not correlated with time- and frequency-domain analysis of HRV. Conclusions: PIIINP was significantly correlated with time- and frequency-domain analysis of HRV in HF patients. PIIINP is a potential serological marker to evaluate cardiac autonomic control and risk of SCD in HF patients. ? 2010 by Walter de Gruyter Berlin New York. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Clinical Chemistry and Laboratory Medicine | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | angiotensin receptor antagonist; beta adrenergic receptor blocking agent; digoxin; dipeptidyl carboxypeptidase inhibitor; loop diuretic agent; procollagen type 3 aminopropeptide; spironolactone; adult; aged; article; clinical article; disease marker; electrocardiography; extracellular matrix; female; heart failure; heart function; heart left ventricle ejection fraction; heart rate variability; human; male; priority journal; protein blood level; sudden death; Autonomic Nervous System; Biological Markers; Collagen Type III; Death, Sudden, Cardiac; Electrocardiography, Ambulatory; Extracellular Matrix; Female; Heart Failure; Heart Rate; Humans; Male; Middle Aged | - |
dc.title | The relationship between aminoterminal propeptide of type III procollagen and heart rate variability parameters in heart failure patients: A potential serum marker to evaluate cardiac autonomic control and sudden cardiac death | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1515/CCLM.2010.348 | - |
dc.identifier.pmid | 20846104 | - |
dc.identifier.scopus | 2-s2.0-79251510542 | - |
dc.relation.pages | 1821-1827 | en_US |
dc.relation.journalvolume | 48 | en_US |
dc.relation.journalissue | 12 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUHBH | - |
crisitem.author.dept | Nuclear Medicine-NTUH | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUHHC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Public Health | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0001-8153-1441 | - |
crisitem.author.orcid | 0000-0003-1046-2308 | - |
crisitem.author.orcid | 0000-0003-1520-1166 | - |
crisitem.author.orcid | 0000-0002-7794-497X | - |
crisitem.author.orcid | 0000-0002-2804-7447 | - |
crisitem.author.orcid | 0000-0001-7935-0991 | - |
crisitem.author.orcid | 0000-0003-3201-4143 | - |
crisitem.author.orcid | 0000-0002-1075-5787 | - |
crisitem.author.orcid | 0000-0003-4979-8351 | - |
crisitem.author.orcid | 0000-0001-6633-7632 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital Bei-Hu Branch | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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