https://scholars.lib.ntu.edu.tw/handle/123456789/471020
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | YEN-WEN WU | en_US |
dc.contributor.author | YING-HSIEN CHEN | en_US |
dc.contributor.author | SHOEI-SHEN WANG | en_US |
dc.contributor.author | Jui H.-Y. | en_US |
dc.contributor.author | RUOH-FANG YEN | en_US |
dc.contributor.author | KAI-YUAN TZEN | en_US |
dc.contributor.author | MING-FONG CHEN | en_US |
dc.contributor.author | CHII-MING LEE | en_US |
dc.creator | Wu Y.-W.;Chen Y.-H.;Shoei-Shen Wang;Jui H.-Y.;Yen R.-F.;Tzen K.-Y.;Chen M.-F.;Lee C.-M. | - |
dc.date.accessioned | 2020-03-05T08:37:55Z | - |
dc.date.available | 2020-03-05T08:37:55Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0161-5505 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77953920164&doi=10.2967%2fjnumed.109.073833&partnerID=40&md5=a7fc630ec4f87d0330b713b0ce341616 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/471020 | - |
dc.description.abstract | Cardiac allograft vasculopathy (CAV) is the major determinant of long-term survival after heart transplantation. We aimed to evaluate the efficacy of PET as a noninvasive way to assess the early stages of CAV. Methods: Twenty-seven consecutive patients (20 men and 7 women; mean age ± SD, 46 ± 12 y) who had normal results on coronary angiography and normal left ventricular systolic function (ejection fraction ? 60%) were enrolled at 2.5 ± 2.1 y after transplantation. Myocardial blood flow (MBF) was assessed using dynamic 13N-ammonia PET at rest and during adenosine-induced hyperemia, and myocardial perfusion reserve (MPR) was calculated as the ratio of hyperemic MBF to resting MBF. Regional 13N-ammonia PET was assessed using a 5-point scoring system. The intravascular ultrasound (IVUS) measurements for the extent of intimal hyperplasia, including plaque volume index (calculated as [total plaque volume/total vessel volume] × 100%) and maximum area of stenosis, were compared with MPR by linear regression analysis. Results: In 27 angiographically normal cardiac transplant recipients, MBF at rest and during adenosine stress and MPR of the left anterior descending artery distribution correlated strongly with the other 2 coronary artery distribution territories (r ? 0.97, P < 0.0001). Summed stress score and summed difference score showed a moderate inverse correlation with MPR (r = -0.41 and -0.49, respectively; P < 0.05) but not with IVUS measurements. MPR correlated inversely with plaque volume index (r = -0.40, P < 0.05) but not with maximal luminal stenosis as assessed by IVUS. In addition, MPR and IVUS measurements gradually inversely changed after heart transplantation (all P < 0.05). Conclusion: This study confirms that CAV is a progressive process, diffusely involving the epicardial and microvascular coronary system. Plaque burden as determined by IVUS agrees well with MPR as assessed by PET in recipients with normal coronary angiography results. This finding suggests that dynamic 13N-ammonia PET is clinically feasible for the early detection of CAV and can be used as a reliable marker of disease progression. COPYRIGHT ? 2010 by the Society of Nuclear Medicine, Inc. | - |
dc.relation.ispartof | Journal of Nuclear Medicine | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | adenosine; ammonia; nitrogen 13; diagnostic agent; adult; aged; angiocardiography; artery intima proliferation; artery occlusion; article; atherosclerotic plaque; cardiac allograft vasculopathy; clinical article; diagnostic accuracy; diagnostic value; disease course; disease marker; female; graft recipient; heart ejection fraction; heart muscle blood flow; heart muscle perfusion; heart transplantation; human; hyperemia; intravascular ultrasound; left anterior descending coronary artery; male; positron emission tomography; priority journal; scoring system; systolic blood pressure; chemistry; coronary blood vessel; echography; endoscopic echography; heart; heart transplantation; middle aged; pathophysiology; scintiscanning; time; vascular disease; Adult; Aged; Ammonia; Coronary Angiography; Coronary Vessels; Female; Heart; Heart Transplantation; Humans; Male; Middle Aged; Positron-Emission Tomography; Time Factors; Ultrasonography, Interventional; Vascular Diseases; Young Adult | - |
dc.title | PET assessment of myocardial perfusion reserve inversely correlates with intravascular ultrasound findings in angiographically normal cardiac transplant recipients | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.2967/jnumed.109.073833 | - |
dc.identifier.pmid | 20484427 | - |
dc.identifier.scopus | 2-s2.0-77953920164 | - |
dc.relation.pages | 906-912 | - |
dc.relation.journalvolume | 51 | - |
dc.relation.journalissue | 6 | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Nuclear Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Nuclear Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-1520-1166 | - |
crisitem.author.orcid | 0000-0002-0585-5847 | - |
crisitem.author.orcid | 0000-0003-3201-4143 | - |
crisitem.author.orcid | 0000-0003-1648-6482 | - |
crisitem.author.orcid | 0000-0002-5657-8579 | - |
crisitem.author.orcid | 0000-0001-6633-7632 | - |
crisitem.author.orcid | 0000-0002-1075-5787 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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