https://scholars.lib.ntu.edu.tw/handle/123456789/471033
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Liu S.-C. | en_US |
dc.contributor.author | CHIA-TI TSAI | en_US |
dc.contributor.author | CHO-KAI WU | en_US |
dc.contributor.author | Yu M.-F. | en_US |
dc.contributor.author | MU-ZON WU | en_US |
dc.contributor.author | LIANG-IN LIN | en_US |
dc.contributor.author | SHOEI-SHEN WANG | en_US |
dc.contributor.author | HWANG, JUEY-JEN | en_US |
dc.contributor.author | Tseng Y.-Z. | en_US |
dc.contributor.author | FU-TIEN CHIANG | en_US |
dc.contributor.author | Tseng C.-D. | en_US |
dc.creator | Liu S.-C.;Tsai C.-T.;Wu C.-K.;Yu M.-F.;Wu M.-Z.;Lin L.-I.;Shoei-Shen Wang;Hwang J.-J.;Tseng Y.-Z.;Chiang F.-T.;Tseng C.-D. | - |
dc.date.accessioned | 2020-03-05T08:37:58Z | - |
dc.date.available | 2020-03-05T08:37:58Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0188-4409 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-71649088394&doi=10.1016%2fj.arcmed.2009.09.002&partnerID=40&md5=c76e0b465159b9ec49033414ad7dc1f2 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/471033 | - |
dc.description.abstract | Background and Aims: The identification of possible pathogens for an infectious etiology of atherosclerotic coronary artery disease (CAD) is an expanding field. The present study was undertaken to explore the role of parvovirus B19, a potent infectious agent. Methods: A total of 565 patients were analyzed (90 patients with CAD, and 475 controls). Serologic analysis for human paravovirus B19 (B19) specific IgM and IgG was carried out in all patients. In addition, tissue specimens were obtained from five patients who received heart transplants. Direct in situ polymerase chain reaction (PCR) and immunocytochemistry were performed in the samples to localize B19 DNA. Results: Enzyme immunoassay showed that the seropositive rate of anti-B19 IgG in patients with CAD was 1.5- to 2.7-fold more frequent than in healthy controls. Clinical characteristics did not affect the prevalence of seropositivity for B19. However, anti-B19 IgM and B19-specific DNA were not detected in healthy or individuals with CAD. Furthermore, nonradioactive in situ PCR found that the majority of B19-specific DNA was located in the endothelial cells of the thickened intima. Conclusions: Our results first demonstrate a seroepidemiological and histopathological association between chronic B19 infection and CAD, suggesting that B19 infection may have a potential role in the pathogenesis of coronary atherosclerosis. ? 2009 IMSS. | - |
dc.relation.ispartof | Archives of Medical Research | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | immunoglobulin G; immunoglobulin M; nucleic acid; virus DNA; adult; aged; artery wall; article; blood vessel wall; controlled study; coronary artery atherosclerosis; disease association; enzyme immunoassay; female; gene location; histopathology; human; human tissue; immunocytochemistry; major clinical study; male; nonhuman; parvovirus infection; polymerase chain reaction; seroepidemiology; serology; virus examination; virus pathogenesis; Adult; Aged; Antibodies, Viral; Arteries; Coronary Artery Disease; DNA, Viral; Humans; Immunoglobulin G; Immunoglobulin M; Male; Middle Aged; Parvoviridae Infections; Parvovirus B19, Human | - |
dc.title | Human Parvovirus B19 Infection in Patients with Coronary Atherosclerosis | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.arcmed.2009.09.002 | - |
dc.identifier.pmid | 20082878 | - |
dc.identifier.scopus | 2-s2.0-71649088394 | - |
dc.relation.pages | 612-617 | - |
dc.relation.journalvolume | 40 | - |
dc.relation.journalissue | 7 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Forensic Medicine | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-4853-8665 | - |
crisitem.author.orcid | 0000-0002-3867-150X | - |
crisitem.author.orcid | 0000-0002-7509-1643 | - |
crisitem.author.orcid | 0000-0002-3561-1093 | - |
crisitem.author.orcid | 0000-0003-3201-4143 | - |
crisitem.author.orcid | 0000-0001-6437-0455 | - |
crisitem.author.orcid | 0000-0003-4936-8968 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
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