https://scholars.lib.ntu.edu.tw/handle/123456789/471036
Title: | Elevated blood urea nitrogen-to-creatinine ratio increased the risk of hospitalization and all-cause death in patients with chronic heart failure | Authors: | HUNG-JU LIN CHIA-LUN CHAO KUO-LIONG CHIEN YI-LWUN HO CHII-MING LEE YEN-HUNG LIN YEN-WEN WU RON-BIN HSU NAI-KUAN CHOU SHOEI-SHEN WANG Chen C.-Y. MING-FONG CHEN |
Issue Date: | 2009 | Journal Volume: | 98 | Journal Issue: | 8 | Start page/Pages: | 487-492 | Source: | Clinical Research in Cardiology | Abstract: | Objectives: To examine the relationship between blood urea nitrogen (BUN)-to-creatinine ratio and the prognosis of chronic heart failure (HF). Methods: We analyzed the data from the cohort of 243 adult patients with chronic HF followed at the HF clinic in a tertiary medical center between December 2003 and June 2006. Primary endpoints were the events of all-cause death and first hospitalization for HF. Results: During a median follow-up of 1.2 years, 72 events were recorded with an event rate of 25.7 events per 100 person-years. In multivariate-adjusted Cox regression models, elevated BUN-to-creatinine ratio was associated with a heightened risk of hospitalization and all-cause death [hazard ratio (HR), 1.24; 95% confidence interval (CI), 1.02-1.51]. The relationship remained after adjusting for glomerular filtration rate (GFR) (HR, 1.23; 95% CI, 1.01-1.51). There was a linear trend toward increasing risks of adverse outcomes across the tertiles of BUN-to-creatinine ratio (P = 0.02). The coexisting presence of the third tertile of BUN-to-creatinine ratio and GFR < 60 ml/min/1.73 m2 tended to pose a synergistic risk for hospitalization and all-cause death (relative risk, 2.29), relative to those at the first and second tertiles who had GFR ? 60 ml/min/1.73m2. Conclusions: An elevated BUN-to-creatinine ratio, independent of GFR, confers an increased risk of hospitalization and all-cause death in patients with chronic HF. ? 2009 Springer-Verlag. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-68749088337&doi=10.1007%2fs00392-009-0025-1&partnerID=40&md5=a070fa77c62ef156e8e79862f5603d10 https://scholars.lib.ntu.edu.tw/handle/123456789/471036 |
ISSN: | 1861-0684 | DOI: | 10.1007/s00392-009-0025-1 | SDG/Keyword: | creatinine; urea; adult; aged; article; cardiovascular risk; controlled study; creatinine blood level; female; glomerulus filtration rate; heart failure; hospitalization; human; major clinical study; male; mortality; urea nitrogen blood level; Aged; Biological Markers; Blood Urea Nitrogen; Cause of Death; Chronic Disease; Creatinine; Female; Heart Failure; Hospitalization; Humans; Incidence; Male; Middle Aged; Risk Assessment; Risk Factors; Sensitivity and Specificity; Survival Analysis; Survival Rate; Taiwan |
Appears in Collections: | 醫學系 |
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