https://scholars.lib.ntu.edu.tw/handle/123456789/471206
標題: | Low incidence of transplant coronary artery disease in Chinese heart recipients | 作者: | RON-BIN HSU Chu S.-H. SHOEI-SHEN WANG Ko W.-J. NAI-KUAN CHOU CHII-MING LEE Chen M.-F. Lee Y.-T. |
公開日期: | 1999 | 卷: | 33 | 期: | 6 | 起(迄)頁: | 1573-1577 | 來源出版物: | Journal of the American College of Cardiology | 摘要: | OBJECTIVES: This study sought to assess the incidence of transplant coronary artery disease (CAD) in Chinese heart recipients. BACKGROUND: The prevalence of transplant CAD detected by angiography at 1, 2 and 4 years after heart transplantation was 11%, 22% and 45%, respectively. The incidence of transplant CAD in Chinese heart recipients has not been reported. METHODS: For those recipients surviving for more than 1 year after transplantation, coronary angiography was performed annually for surveillance of transplant CAD. The recipient characteristics, donor characteristics, rejection episodes, medication and human leukocyte antigen (HLA) mismatches were recorded. RESULTS: Fifty patients were included in this study. Thirteen (260%) recipients had ischemic heart disease. Two patients (40%) had active cytomegalovirus (CMV) infection after transplantation. The mean number of rejection episodes in the 1st year after transplantation was 1.15. Among 47 patients with complete data of donor and recipient histocompatibility antigens, there were seven patients (14.9%) with two or fewer HLA mismatches. Among 74 angiograms of 50 patients reviewed, only one patient had discrete stenosis less than 50% in the middle portion of the left anterior descending artery at 1 year after transplantation. The cumulative incidence of transplant CAD was 2% at 1 year and 2% at 2 and 4 years after transplantation. CONCLUSIONS: The incidence of transplant CAD was low in Chinese heart transplant recipients. Low percentage of ischemic heart disease in recipients, low occurrence of active CMV infection and rejection episodes after transplantation, less racial disparity, and lower HLA mismatches may be the important factors. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033133394&doi=10.1016%2fS0735-1097%2899%2900060-1&partnerID=40&md5=9befdba53753a0e1b2b3c0e1673f7aec https://scholars.lib.ntu.edu.tw/handle/123456789/471206 http://ntur.lib.ntu.edu.tw//handle/246246/91502 |
ISSN: | 0735-1097 | DOI: | 10.1016/S0735-1097(99)00060-1 | SDG/關鍵字: | adult; angiocardiography; article; chinese; clinical article; coronary artery disease; coronary artery obstruction; cytomegalovirus infection; female; heart transplantation; human; incidence; left anterior descending coronary artery; male; prevalence; priority journal; Adolescent; Adult; Asian Continental Ancestry Group; Coronary Disease; Cross-Cultural Comparison; Cross-Sectional Studies; Cytomegalovirus Infections; Female; Follow-Up Studies; Graft Rejection; Heart Transplantation; Histocompatibility Testing; Humans; Incidence; Male; Middle Aged; Postoperative Complications; Taiwan; United States |
顯示於: | 醫學系 |
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