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  1. NTU Scholars
  2. 醫學院
  3. 病理學科所
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/473305
Title: Prognostic Significance of CDCP1 Expression in Colorectal Cancer and Effect of Its Inhibition on Invasion and Migration
Authors: Chou C.-T.
Li Y.-J.
Chang C.-C.
Yang C.-N.
Li P.-S.
YUNG-MING JENG 
Chen S.-T.
Kuo M.-L.
Lin I.-C.
Lin B.-R.
Issue Date: 2015
Publisher: Springer New York LLC
Journal Volume: 22
Journal Issue: 13
Start page/Pages: 4335-4343
Source: Annals of Surgical Oncology
Abstract: 
Background: To assess the correlations and functions of complement C1r/C1s, Uegf, Bmp1 domain-containing protein-1 (CDCP1) in identifying colorectal cancer (CRC) patients who are at high risk for metastasis. Methods: Tumor specimens from 101 patients were analyzed by real-time polymerase chain reaction to detect CDCP1 expression. CDCP1 expression plasmids and shRNA were used to knock down CDCP1 expression in this study to investigate migratory and invasive abilities by Boyden chambers. The mRNA expression profiles in shCDCP1 transfectants were compared to those in control cells by conducting microarray analysis. Its downstream effectors were also invested in this study. Results: CRC patients with a high CDCP1 expression had a statistically significant lower overall survival and disease-free survival compared to those exhibiting low CDCP1 expression. In vitro, knock-down CDCP1 expression significantly decreased migratory and invasive abilities in HCT116. Aberrant expression of CDCP1 increased cancer cell migration and invasion. By using integrated genomics, we identified ROCK1 (rho-associated, coiled-coil-containing protein kinase 1 pseudogene 1) as a downstream effector in CDCP1-mediated migration and as an invasion mediator. Clinically, ROCK1 and CDCP1 mRNA expression exhibited a strong positive correlation in CRC patient samples. Conclusions: Our results implicated CDCP1 as a key regulator of CRC migration and invasion, and suggest that it is a useful prognostic factor for patients with CRC. Improved identification of a high-risk subset of early metastatic patients may guide indications of individualized treatment in clinical practice. ? 2015, Society of Surgical Oncology.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84947128398&doi=10.1245%2fs10434-015-4505-4&partnerID=40&md5=142b4139b67cf3aa3eb29679cb88a6f3
https://scholars.lib.ntu.edu.tw/handle/123456789/473305
ISSN: 1068-9265
DOI: 10.1245/s10434-015-4505-4
metadata.dc.subject.other: complement component C1r; complement component C1s; domain containing protein 1; messenger RNA; procollagen C proteinase; protein; rho associated coiled coil-containing protein kinase 1 pseudogene 1; short hairpin RNA; uegf protein; unclassified drug; CDCP1 protein, human; cell adhesion molecule; leukocyte antigen; messenger RNA; small interfering RNA; tumor marker; tumor protein; adult; aged; animal experiment; animal model; Article; cancer prognosis; cancer staging; cell adhesion; cell migration; clinical practice; colorectal cancer; controlled study; correlation analysis; disease free survival; female; genomics; high risk patient; human; human cell; in vitro study; male; metastasis; microarray analysis; mouse; nonhuman; overall survival; plasmid; protein analysis; protein expression; protein function; real time polymerase chain reaction; recurrence free survival; tumor invasion; antagonists and inhibitors; cell motion; cell proliferation; colorectal tumor; follow up; genetics; lymph node metastasis; mortality; pathology; prognosis; reverse transcription polymerase chain reaction; survival rate; tumor cell culture; tumor recurrence; Aged; Antigens, CD; Biomarkers, Tumor; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Female; Follow-Up Studies; Humans; Lymphatic Metastasis; Male; Neoplasm Invasiveness; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Survival Rate; Tumor Cells, Cultured
[SDGs]SDG3
Appears in Collections:病理學科所

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

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