https://scholars.lib.ntu.edu.tw/handle/123456789/473325
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wu H.-H. | en_US |
dc.contributor.author | Hwang-Verslues W.W. | en_US |
dc.contributor.author | Lee W.-H. | en_US |
dc.contributor.author | Huang C.-K. | en_US |
dc.contributor.author | Wei P.-C. | en_US |
dc.contributor.author | Chen C.-L. | en_US |
dc.contributor.author | Shew J.-Y. | en_US |
dc.contributor.author | Lee E.-Y.-H.P. | en_US |
dc.contributor.author | YUNG-MING JENG | en_US |
dc.contributor.author | YU-WEN TIEN | en_US |
dc.contributor.author | Ma C. | en_US |
dc.contributor.author | Lee W.-H. | en_US |
dc.creator | Wu H.-H.;Hwang-Verslues W.W.;Lee W.-H.;Huang C.-K.;Wei P.-C.;Chen C.-L.;Shew J.-Y.;Lee E.-Y.-H.P.;Yung-Ming Jeng;Tien Y.-W.;Ma C.;Lee W.-H. | - |
dc.date.accessioned | 2020-03-06T08:25:03Z | - |
dc.date.available | 2020-03-06T08:25:03Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0022-1007 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84924700441&doi=10.1084%2fjem.20141702&partnerID=40&md5=c90590c01fea3919635dfd976461dacb | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/473325 | - |
dc.description.abstract | Pancreatic cancer has an extremely high mortality rate due to its aggressive metastatic nature. Resolving the underlying mechanisms will be crucial for treatment. Here, we found that overexpression of IL-17B receptor (IL-17RB) strongly correlated with postoperative metastasis and inversely correlated with progression-free survival in pancreatic cancer patients. Consistently, results from ex vivo experiments further validated that IL-17RB and its ligand, IL-17B, plays an essential role in pancreatic cancer metastasis and malignancy. Signals from IL-17B-IL-17RB activated CCL20/CXCL1/IL-8/TFF1 chemokine expressions via the ERK1/2 pathway to promote cancer cell invasion, macrophage and endothelial cell recruitment at primary sites, and cancer cell survival at distant organs. Treatment with a newly derived monoclonal antibody against IL-17RB blocked tumor metastasis and promoted survival in a mouse xenograft model. These findings not only illustrate a key mechanism underlying the highly aggressive characteristics of pancreatic cancer but also provide a practical approach to tackle this disease. ? 2015 Wu et al. | - |
dc.publisher | Rockefeller University Press | - |
dc.relation.ispartof | Journal of Experimental Medicine | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | antineoplastic agent; CXCL1 chemokine; cytokine; interleukin 17B; interleukin 17B receptor; interleukin 17B receptor antibody; interleukin 8; macrophage inflammatory protein 3alpha; mitogen activated protein kinase; monoclonal antibody; unclassified drug; chemokine; interleukin 17; interleukin 17 receptor; monoclonal antibody; adult; animal experiment; animal model; antineoplastic activity; Article; cancer cell; cancer growth; cancer inhibition; cancer localization; cancer survival; cell invasion; drug targeting; endothelium cell; female; gene overexpression; human; macrophage; male; metastasis; mouse; nonhuman; pancreas cancer; priority journal; progression free survival; signal transduction; animal; disease free survival; drug screening; gene expression regulation; genetics; immunology; metabolism; middle aged; mortality; Pancreatic Neoplasms; pathology; SCID mouse; Animals; Antibodies, Monoclonal; Chemokines; Disease-Free Survival; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukin-17; Male; Mice, SCID; Middle Aged; Pancreatic Neoplasms; Receptors, Interleukin-17; Signal Transduction; Xenograft Model Antitumor Assays | - |
dc.title | Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1084/jem.20141702 | - |
dc.identifier.pmid | 25732306 | - |
dc.identifier.scopus | 2-s2.0-84924700441 | - |
dc.relation.pages | 333-349 | - |
dc.relation.journalvolume | 212 | - |
dc.relation.journalissue | 3 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.orcid | 0000-0002-3878-4491 | - |
crisitem.author.orcid | 0000-0002-9126-2705 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 病理學科所 |
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