https://scholars.lib.ntu.edu.tw/handle/123456789/473336
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Su M.-C. | en_US |
dc.contributor.author | Chen C.-T. | en_US |
dc.contributor.author | Huang F.-I. | en_US |
dc.contributor.author | Chen Y.-L. | en_US |
dc.contributor.author | YUNG-MING JENG | en_US |
dc.contributor.author | Lin C.-Y. | en_US |
dc.creator | Su M.-C.;Chen C.-T.;Huang F.-I.;Chen Y.-L.;Yung-Ming Jeng;Lin C.-Y. | - |
dc.date.accessioned | 2020-03-06T08:25:05Z | - |
dc.date.available | 2020-03-06T08:25:05Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0929-6646 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84918782904&doi=10.1016%2fj.jfma.2013.07.012&partnerID=40&md5=37d4a2d46370ad4d28aa46946aac36fe | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/473336 | - |
dc.description.abstract | Background/Purpose: Lymphoid-enhancing factor 1 (LEF1) is a transcription factor mediating Wnt/β-catenin signaling. In this study, we analyzed the clinicopathologic significance of LEF1 expression in oral squamous cell carcinoma (OSCC). Methods: Expression levels of LEF1 in 135 cases of OSCC were determined by immunohistochemistry. The results were correlated with clinicopathologic parameters and patient outcome. Results: LEF1 was only occasionally detected in basal and parabasal cells of nontumorous squamous epithelium. Overexpression of LEF1 was observed in 33 of 135 OSCCs (24%). LEF1 was more frequently expressed in moderately to poorly differentiated cancer (. p=0.0035) and was associated with lymphovascular invasion (. p=0.0252). Overexpression of LEF1 was significantly associated with poor prognosis (. p=0.0176, hazard ratio=1.96, 95% CI=1.02-3.75). Multivariate analysis revealed LEF1expression and margin status to be the significant independent predictors for overall survival. Conclusion: Our study suggests LEF1 expression in OSCC may play an important role in tumor progression and can be served as a predictor of poor prognosis for patients with OSCC. ? 2013. | - |
dc.publisher | Elsevier | - |
dc.relation.ispartof | Journal of the Formosan Medical Association | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | lymphoid enhancer factor 1; LEF1 protein, human; lymphoid enhancer factor 1; adult; Article; cancer patient; cancer prognosis; controlled study; female; histopathology; human; human tissue; immunohistochemistry; lymph vessel metastasis; major clinical study; male; mouth squamous cell carcinoma; nucleotide sequence; overall survival; protein expression; tumor growth; cancer grading; Carcinoma, Squamous Cell; chemistry; middle aged; minimal residual disease; Mouth Neoplasms; pathology; prognosis; survival rate; tumor invasion; Carcinoma, Squamous Cell; Female; Humans; Lymphoid Enhancer-Binding Factor 1; Male; Middle Aged; Mouth Neoplasms; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm, Residual; Prognosis; Survival Rate | - |
dc.title | Expression of LEF1 is an independent prognostic factor for patients with oral squamous cell carcinoma | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jfma.2013.07.012 | - |
dc.identifier.pmid | 24021930 | - |
dc.identifier.scopus | 2-s2.0-84918782904 | - |
dc.relation.pages | 934-939 | - |
dc.relation.journalvolume | 113 | - |
dc.relation.journalissue | 12 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.orcid | 0000-0002-3878-4491 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 病理學科所 |
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