https://scholars.lib.ntu.edu.tw/handle/123456789/473339
標題: | The occurrence of primary hepatic adenoma in deceased donor renal transplant recipient | 作者: | YU-TSO LIAO YUNG-MING JENG Lee, Yu-Hsin MENG-KUN TSAI REY-HENG HU MING-CHIH HO |
公開日期: | 2014 | 卷: | 40 | 期: | 1 | 起(迄)頁: | 118-122 | 來源出版物: | International Braz J Urol | 摘要: | Main findings: We reported a case of new-onset, multi-focal hepatic adenoma in an 18 year-old man with no classic risk factors occurring forty months after a renal transplant from a cadaver donor. Histopathology of the adenoma was examined and genotype and phenotype were also analyzed. Histopathologic examination of the adenoma showed no malignancy. Genotype and phenotype analysis revealed no HNF1α or β-catenin gene mutations and no inflammatory infiltration. The patient was well and disease-free postoperatively. Case hypothesis: Hepatic adenoma occurs mostly in those taking oral contraceptives or androgenic-anabolic steroids or in those with hereditary diseases. Hepatic adenoma in a renal transplant recipient is rare and has only been reported in one case with glycogen storage disease type Ia. Immunosuppressive treatment might have contributed to the development of the neoplasm. Promising future implications: Although malignant change occurs most often in β-catenin gene mutation hepatic adenoma, surgical resection of the adenoma in a patient under immunosuppressive therapy should be considered in order to avoid the possibility of malignant transformation or hemorrhagic rupture. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84897874815&doi=10.1590%2fS1677-5538.IBJU.2014.01.17&partnerID=40&md5=ce451ca5b2d6d5dd9fa3c90395c79a2a https://scholars.lib.ntu.edu.tw/handle/123456789/473339 |
ISSN: | 1677-5538 | DOI: | 10.1590/S1677-5538.IBJU.2014.01.17 | SDG/關鍵字: | beta catenin; glycoprotein gp 130; IL6ST protein, human; immunosuppressive agent; adenoma; adolescent; article; biopsy; cadaver; donor; genetics; human; immunohistochemistry; kidney transplantation; liver tumor; male; pathology; Adenoma; Adolescent; beta Catenin; Biopsy; Cadaver; Cytokine Receptor gp130; Humans; Immunohistochemistry; Immunosuppressive Agents; Kidney Transplantation; Liver Neoplasms; Male; Tissue Donors |
顯示於: | 病理學科所 |
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