https://scholars.lib.ntu.edu.tw/handle/123456789/473364
標題: | Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility | 作者: | Kuo T.-C. CHING-TING TAN Chang Y.-W. Hong C.-C. Lee W.-J. Chen M.-W. YUNG-MING JENG Chiou J. Yu P. Chen P.-S. Wang M.-Y. Hsiao M. Su J.-L. Kuo M.-L. |
公開日期: | 2013 | 卷: | 123 | 期: | 3 | 起(迄)頁: | 1082-1095 | 來源出版物: | Journal of Clinical Investigation | 摘要: | Angiopoietin-like protein 1 (ANGPTL1) is a potent regulator of angiogenesis. Growing evidence suggests that ANGPTL family proteins not only target endothelial cells but also affect tumor cell behavior. In a screen of 102 patients with lung cancer, we found that ANGPTL1 expression was inversely correlated with invasion, lymph node metastasis, and poor clinical outcomes. ANGPTL1 suppressed the migratory, invasive, and metastatic capabilities of lung and breast cancer cell lines in vitro and reduced metastasis in mice injected with cancer cell lines overexpressing ANGPTL1. Ectopic expression of ANGPTL1 suppressed the epithelial-to-mesenchymal transition (EMT) by reducing the expression of the zinc-finger protein SLUG. A microRNA screen revealed that ANGPTL1 suppressed SLUG by inducing expression of miR-630 in an integrin α1β1/FAK/ERK/SP1 pathway-dependent manner. These results demonstrate that ANGPTL1 represses lung cancer cell motility by abrogating the expression of the EMT mediator SLUG. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84874644402&doi=10.1172%2fJCI64044&partnerID=40&md5=5d6e025d69e25bffc78f2cd816df9d4b https://scholars.lib.ntu.edu.tw/handle/123456789/473364 |
ISSN: | 0021-9738 | DOI: | 10.1172/JCI64044 | SDG/關鍵字: | angiopoietin 1; CCAAT enhancer binding protein alpha; fibronectin; microRNA; microRNA 630; nerve cell adhesion molecule; transcription factor Slug; transcription factor Sp1; unclassified drug; uvomorulin; very late activation antigen 1; vimentin; animal cell; animal experiment; animal model; animal tissue; article; cancer cell culture; cancer inhibition; cancer invasion; cancer prognosis; cell invasion; cell migration; cell motility; controlled study; disease free survival; down regulation; female; gene overexpression; human; human cell; human tissue; in vitro study; lung adenocarcinoma; lung alveolus cell carcinoma; lymph node metastasis; male; mouse; nonhuman; nucleotide sequence; outcome assessment; overall survival; priority journal; protein expression; regulatory mechanism; signal transduction |
顯示於: | 病理學科所 |
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