https://scholars.lib.ntu.edu.tw/handle/123456789/473368
Title: | MiR-520h-mediated FOXC2 regulation is critical for inhibition of lung cancer progression by resveratrol | Authors: | Yu Y.-H. Chen H.-A. Chen P.-S. Cheng Y.-J. Hsu W.-H. Chang Y.-W. Chen Y.-H. Jan Y. Hsiao M. Chang T.-Y. Liu Y.-H. YUNG-MING JENG Wu C.-H. Huang M.-T. Su Y.-H. Hung M.-C. Chien M.-H. Chen C.-Y. Kuo M.-L. Su J.-L. |
Issue Date: | 2013 | Journal Volume: | 32 | Journal Issue: | 4 | Start page/Pages: | 431-443 | Source: | Oncogene | Abstract: | Resveratrol, a phytochemical found in various plants and Chinese herbs, is associated with multiple tumor-suppressing activities, has been tested in clinical trials. However, the molecular mechanisms involved in resveratrol-mediated tumor suppressing activities are not yet completely defined. Here, we showed that treatment with resveratrol inhibited cell mobility through induction of the mesenchymal-epithelial transition (MET) in lung cancer cells. We also found that downregulation of FOXC2 (forkhead box C2) is critical for resveratrol-mediated suppression of tumor metastasis in an in vitro and in vivo models. We also identified a signal cascade, namely, resveratrol - |miRNA-520h - |PP2A/C - |Akt → NF-κB → FOXC2, in which resveratrol inhibited the expression of FOXC2 through regulation of miRNA-520h-mediated signal cascade. This study identified a new miRNA-520h-related signal cascade involved in resveratrol-mediated tumor suppression activity and provide the clinical significances of miR-520h, PP2A/C and FOXC2 in lung cancer patients. Our results indicated a functional link between resveratrol-mediated miRNA-520h regulation and tumor suppressing ability, and provide a new insight into the role of resveratrol-induced molecular and epigenetic regulations in tumor suppression. ? 2013 Macmillan Publishers Limited. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84873056468&doi=10.1038%2fonc.2012.74&partnerID=40&md5=6e5296538866603cc99e159bd509240a https://scholars.lib.ntu.edu.tw/handle/123456789/473368 |
ISSN: | 0950-9232 | DOI: | 10.1038/onc.2012.74 | SDG/Keyword: | immunoglobulin enhancer binding protein; microRNA; microRNA 520h; protein kinase B; resveratrol; transcription factor FOXC2; unclassified drug; animal experiment; animal model; article; cancer cell; cancer growth; cancer inhibition; cancer patient; cell motility; controlled study; down regulation; drug mechanism; enzyme inactivation; epithelial mesenchymal transition; female; human; in vitro study; in vivo study; lung cancer; male; mouse; nonhuman; priority journal; protein expression; regulatory mechanism; signal transduction; Animals; Antineoplastic Agents, Phytogenic; Cell Line; Cell Line, Tumor; Cell Movement; Disease Progression; Down-Regulation; Epithelial-Mesenchymal Transition; Female; Forkhead Transcription Factors; HEK293 Cells; Humans; Lung Neoplasms; Mice; Mice, SCID; MicroRNAs; NF-kappa B; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt; Stilbenes; Xenograft Model Antitumor Assays |
Appears in Collections: | 病理學科所 |
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