https://scholars.lib.ntu.edu.tw/handle/123456789/473368
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Yu Y.-H. | en_US |
dc.contributor.author | Chen H.-A. | en_US |
dc.contributor.author | Chen P.-S. | en_US |
dc.contributor.author | Cheng Y.-J. | en_US |
dc.contributor.author | Hsu W.-H. | en_US |
dc.contributor.author | Chang Y.-W. | en_US |
dc.contributor.author | Chen Y.-H. | en_US |
dc.contributor.author | Jan Y. | en_US |
dc.contributor.author | Hsiao M. | en_US |
dc.contributor.author | Chang T.-Y. | en_US |
dc.contributor.author | Liu Y.-H. | en_US |
dc.contributor.author | YUNG-MING JENG | en_US |
dc.contributor.author | Wu C.-H. | en_US |
dc.contributor.author | Huang M.-T. | en_US |
dc.contributor.author | Su Y.-H. | en_US |
dc.contributor.author | Hung M.-C. | en_US |
dc.contributor.author | Chien M.-H. | en_US |
dc.contributor.author | Chen C.-Y. | en_US |
dc.contributor.author | Kuo M.-L. | en_US |
dc.contributor.author | Su J.-L. | en_US |
dc.creator | Su J.-L.;Kuo M.-L.;Chen C.-Y.;Chien M.-H.;Hung M.-C.;Su Y.-H.;Huang M.-T.;Wu C.-H.;YUNG-MING JENG;Liu Y.-H.;Chang T.-Y.;Hsiao M.;Jan Y.;Chen Y.-H.;Chang Y.-W.;Hsu W.-H.;Cheng Y.-J.;Chen P.-S.;Chen H.-A.;Yu Y.-H. | - |
dc.date.accessioned | 2020-03-06T08:25:11Z | - |
dc.date.available | 2020-03-06T08:25:11Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84873056468&doi=10.1038%2fonc.2012.74&partnerID=40&md5=6e5296538866603cc99e159bd509240a | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/473368 | - |
dc.description.abstract | Resveratrol, a phytochemical found in various plants and Chinese herbs, is associated with multiple tumor-suppressing activities, has been tested in clinical trials. However, the molecular mechanisms involved in resveratrol-mediated tumor suppressing activities are not yet completely defined. Here, we showed that treatment with resveratrol inhibited cell mobility through induction of the mesenchymal-epithelial transition (MET) in lung cancer cells. We also found that downregulation of FOXC2 (forkhead box C2) is critical for resveratrol-mediated suppression of tumor metastasis in an in vitro and in vivo models. We also identified a signal cascade, namely, resveratrol - |miRNA-520h - |PP2A/C - |Akt → NF-κB → FOXC2, in which resveratrol inhibited the expression of FOXC2 through regulation of miRNA-520h-mediated signal cascade. This study identified a new miRNA-520h-related signal cascade involved in resveratrol-mediated tumor suppression activity and provide the clinical significances of miR-520h, PP2A/C and FOXC2 in lung cancer patients. Our results indicated a functional link between resveratrol-mediated miRNA-520h regulation and tumor suppressing ability, and provide a new insight into the role of resveratrol-induced molecular and epigenetic regulations in tumor suppression. ? 2013 Macmillan Publishers Limited. | - |
dc.relation.ispartof | Oncogene | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | immunoglobulin enhancer binding protein; microRNA; microRNA 520h; protein kinase B; resveratrol; transcription factor FOXC2; unclassified drug; animal experiment; animal model; article; cancer cell; cancer growth; cancer inhibition; cancer patient; cell motility; controlled study; down regulation; drug mechanism; enzyme inactivation; epithelial mesenchymal transition; female; human; in vitro study; in vivo study; lung cancer; male; mouse; nonhuman; priority journal; protein expression; regulatory mechanism; signal transduction; Animals; Antineoplastic Agents, Phytogenic; Cell Line; Cell Line, Tumor; Cell Movement; Disease Progression; Down-Regulation; Epithelial-Mesenchymal Transition; Female; Forkhead Transcription Factors; HEK293 Cells; Humans; Lung Neoplasms; Mice; Mice, SCID; MicroRNAs; NF-kappa B; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt; Stilbenes; Xenograft Model Antitumor Assays | - |
dc.title | MiR-520h-mediated FOXC2 regulation is critical for inhibition of lung cancer progression by resveratrol | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/onc.2012.74 | - |
dc.identifier.pmid | 22410781 | - |
dc.identifier.scopus | 2-s2.0-84873056468 | - |
dc.relation.pages | 431-443 | - |
dc.relation.journalvolume | 32 | - |
dc.relation.journalissue | 4 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.orcid | 0000-0002-3878-4491 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 病理學科所 |
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