https://scholars.lib.ntu.edu.tw/handle/123456789/473375
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Kao Y.-C. | en_US |
dc.contributor.author | Lin M.-C. | en_US |
dc.contributor.author | WEI-CHOU LIN | en_US |
dc.contributor.author | YUNG-MING JENG | en_US |
dc.contributor.author | TSUI-LIEN MAO | en_US |
dc.creator | Kao Y.-C.;Lin M.-C.;Lin W.-C.;Yung-Ming Jeng;Mao T.-L. | - |
dc.date.accessioned | 2020-03-06T08:25:13Z | - |
dc.date.available | 2020-03-06T08:25:13Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0309-0167 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84868126411&doi=10.1111%2fj.1365-2559.2012.04267.x&partnerID=40&md5=2693b986a496b05868193b4c8b8dc9b9 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/473375 | - |
dc.description.abstract | Aims: Overexpression of hepatocyte nuclear factor-1β (HNF-1β) has been found in ovarian clear cell carcinoma (OCCC) but not in other types of ovarian carcinoma. The aim of this study was to clarify whether the overexpression of HNF-1β is specific for OCCC, and does not occur in ovarian carcinoma with clear cell change. Methods and results: Immunohistochemistry was performed on 178 ovarian carcinomas with clear cells (80 OCCCs, 60 high-grade serous, 25 endometrioid, and 13 mixed endometrioid and clear cell), 22 ovarian high-grade serous carcinomas without clear cells, 41 renal cell carcinomas (RCCs) and 20 hepatocellular carcinomas (HCCs) with clear cytoplasm. Results were evaluated using an H-score (percentage×intensity). Most OCCCs were diffusely and strongly positive (mean H-score 15.1). High-grade serous carcinoma and endometrioid carcinoma with clear cells were usually negative or focally and weakly positive (mean H-scores 1.5 and 1.7, respectively). High-grade serous carcinoma without clear cells had a mean H-score of 0.77. The mean H-scores of the endometrioid and clear cell components in mixed endometrioid and clear cell carcinoma were 6.2 and 15.7, respectively. HNF-1β was expressed in 95.1% of RCCs and in 30% of HCCs. Conclusions: The diagnosis of ovarian carcinomas with clear cells can be made with greater accuracy by using the intensity and extent of immunoreactivity for HNF-1β. ? 2012 Blackwell Publishing Ltd. | - |
dc.relation.ispartof | Histopathology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | hepatocyte nuclear factor 1beta; tumor marker; article; cancer diagnosis; cancer grading; clear cell carcinoma; controlled study; cytoplasm; diagnostic value; differential diagnosis; endometrioid carcinoma; female; human; human tissue; immunohistochemistry; kidney carcinoma; liver cell carcinoma; major clinical study; ovary carcinoma; priority journal; protein expression; scoring system; Adenocarcinoma, Clear Cell; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Renal Cell; Cystadenocarcinoma, Serous; Female; Hepatocyte Nuclear Factor 1-beta; Humans; Immunohistochemistry; Kidney Neoplasms; Liver Neoplasms; Ovarian Neoplasms; Tumor Markers, Biological | - |
dc.title | Utility of hepatocyte nuclear factor-1β as a diagnostic marker in ovarian carcinomas with clear cells | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1111/j.1365-2559.2012.04267.x | - |
dc.identifier.pmid | 22747504 | - |
dc.identifier.scopus | 2-s2.0-84868126411 | - |
dc.relation.pages | 760-768 | - |
dc.relation.journalvolume | 61 | - |
dc.relation.journalissue | 5 | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.orcid | 0000-0003-2857-3479 | - |
crisitem.author.orcid | 0000-0002-3878-4491 | - |
crisitem.author.orcid | 0000-0002-0159-3691 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 病理學科所 |
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