https://scholars.lib.ntu.edu.tw/handle/123456789/473393
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | YU-YIN SHIH | en_US |
dc.contributor.author | HSIN-YU LEE | en_US |
dc.contributor.author | Nakagawara, Akira | en_US |
dc.contributor.author | HSUEH-FEN JUAN | en_US |
dc.contributor.author | YUNG-MING JENG | en_US |
dc.contributor.author | Tsay, Yeou-Guang | en_US |
dc.contributor.author | DONG-TSAMN LIN | en_US |
dc.contributor.author | FON-JOU HSIEH | en_US |
dc.contributor.author | CHIEN-YUAN PAN | en_US |
dc.contributor.author | WEN-MING HSU | en_US |
dc.contributor.author | Liao Y.-F. | en_US |
dc.creator | Shih Y.-Y. ;Lee H. ;Nakagawara A. ;Juan H.-F. ;Yung-Ming Jeng ;Tsay Y.-G. ;Lin D.-T. ;Hsieh F.-J. ;Pan C.-Y. ;Hsu W.-M. ;Liao Y.-F. | - |
dc.date.accessioned | 2020-03-06T08:25:17Z | - |
dc.date.available | 2020-03-06T08:25:17Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-80054095415&doi=10.1371%2fjournal.pone.0026236&partnerID=40&md5=27bfdfe96c289e6eaa23ddec5232a80e | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/473393 | - |
dc.description.abstract | Retinoic acid (RA) has been approved for the differentiation therapy of neuroblastoma (NB). Previous work revealed a correlation between glucose-regulated protein 75 (GRP75) and the RA-elicited neuronal differentiation of NB cells. The present study further demonstrated that GRP75 translocates into the nucleus and physically interacts with retinoid receptors (RARα and RXRα) to augment RA-elicited neuronal differentiation. GRP75 was required for RARα/RXRα-mediated transcriptional regulation and was shown to reduce the proteasome-mediated degradation of RARα/RXRαin a RA-dependent manner. More intriguingly, the level of GRP75/RARα/RXRα tripartite complexes was tightly associated with the RA-induced suppression of tumor growth in animals and the histological grade of differentiation in human NB tumors. The formation of GRP75/RARα/RXRα complexes was intimately correlated with a normal MYCN copy number of NB tumors, possibly implicating a favorable prognosis of NB tumors. The present findings reveal a novel function of nucleus-localized GRP75 in actively promoting neuronal differentiation, delineating the mode of action for the differentiation therapy of NB by RA. ? 2011 Shih et al. | en_US |
dc.relation.ispartof | PLoS ONE | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | glucose regulated protein 75; proteasome; protein; retinoic acid; retinoic acid receptor; retinoic acid receptor alpha; retinoid X receptor alpha; unclassified drug; glucose regulated proteins; glucose-regulated proteins; heat shock protein 70; membrane protein; MYCN protein, human; nuclear protein; oncoprotein; retinoic acid; retinoic acid receptor; animal experiment; animal model; article; cancer inhibition; cancer therapy; cell nucleus; clinical article; complex formation; controlled study; gene dosage; human; human cell; human tissue; male; mouse; nerve cell differentiation; neuroblastoma; nonhuman; prognosis; protein degradation; protein interaction; protein localization; protein transport; transcription regulation; tumor differentiation; animal; cell differentiation; cell nucleus; DNA responsive element; down regulation; drug effect; drug screening; genetics; metabolism; nerve cell; neuroblastoma; pathology; protein binding; protein multimerization; signal transduction; treatment outcome; Animalia; Animals; Cell Differentiation; Cell Nucleus; Down-Regulation; Gene Dosage; HSP70 Heat-Shock Proteins; Humans; Membrane Proteins; Mice; Neuroblastoma; Neurons; Nuclear Proteins; Oncogene Proteins; Proteasome Endopeptidase Complex; Protein Binding; Protein Multimerization; Protein Transport; Proteolysis; Receptors, Retinoic Acid; Response Elements; Signal Transduction; Treatment Outcome; Tretinoin; Xenograft Model Antitumor Assays | - |
dc.title | Nuclear GRP75 binds retinoic acid receptors to promote neuronal differentiation of neuroblastoma | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1371/journal.pone.0026236 | - |
dc.identifier.pmid | 22022577 | - |
dc.identifier.scopus | 2-s2.0-80054095415 | - |
dc.relation.pages | e26236 | en_US |
dc.relation.journalvolume | 6 | en_US |
dc.relation.journalissue | 10 | en_US |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Life Science | - |
crisitem.author.dept | Center for Biotechnology | - |
crisitem.author.dept | Electrical Engineering | - |
crisitem.author.dept | Molecular and Cellular Biology | - |
crisitem.author.dept | Life Science | - |
crisitem.author.dept | Genome and Systems Biology Degree Program | - |
crisitem.author.dept | Office of Research and Development | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Life Science | - |
crisitem.author.dept | Neurobiology and Cognitive Science Center | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.orcid | 0000-0002-1477-0183 | - |
crisitem.author.orcid | 0000-0003-4876-3309 | - |
crisitem.author.orcid | 0000-0002-3878-4491 | - |
crisitem.author.orcid | 0000-0002-5773-3200 | - |
crisitem.author.orcid | 0000-0002-6654-9309 | - |
crisitem.author.orcid | 0000-0002-5145-9538 | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | Administrative Unit | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 病理學科所 |
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