https://scholars.lib.ntu.edu.tw/handle/123456789/473461
標題: | The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells | 作者: | Su J.-L. PAN-CHYR YANG JIN-YUAN SHIH CHING-YAO YANG LING-HUNG WEI CHANG-YAO HSIEH Chou C.-H. YUNG-MING JENG Wang M.-Y. KING-JEN CHANG Hung M.-C. Kuo M.-L. |
公開日期: | 2006 | 出版社: | Cell Press | 卷: | 9 | 期: | 3 | 起(迄)頁: | 209-223 | 來源出版物: | Cancer Cell | 摘要: | Flt-4, a VEGF receptor, is activated by its specific ligand, VEGF-C. The resultant signaling pathway promotes angiogenesis and/or lymphangiogenesis. This report provides evidence that the VEGF-C/Flt-4 axis enhances cancer cell mobility and invasiveness and contributes to the promotion of cancer cell metastasis. VEGF-C/Flt-4-mediated invasion and metastasis of cancer cells were found to require upregulation of the neural cell adhesion molecule contactin-1 through activation of the Src-p38 MAPK-C/EBP-dependent pathway. Examination of tumor tissues from various types of cancers revealed high levels of Flt-4 and VEGF-C expression that correlated closely with clinical metastasis and patient survival. The VEGF-C/Flt-4 axis, through upregulation of contactin-1, may regulate the invasive capacity in different types of cancer cells. ? 2006 Elsevier Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33644822574&doi=10.1016%2fj.ccr.2006.02.018&partnerID=40&md5=5f627073c77d095ff8af99a66f212dfb https://scholars.lib.ntu.edu.tw/handle/123456789/473461 |
ISSN: | 1535-6108 | DOI: | 10.1016/j.ccr.2006.02.018 | SDG/關鍵字: | contactin; mitogen activated protein kinase; nerve cell adhesion molecule; steroid receptor coactivator 1; vasculotropin C; vasculotropin receptor 3; adult; aged; article; cancer invasion; cancer survival; cell adhesion; cell motility; controlled study; downstream processing; female; histopathology; human; human cell; human tissue; lymph node metastasis; major clinical study; male; metastasis; priority journal; protein expression; signal transduction |
顯示於: | 病理學科所 |
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