https://scholars.lib.ntu.edu.tw/handle/123456789/473466
Title: | Absence of epidermal growth factor receptor exon 18-21 mutation in hepatocellular carcinoma | Authors: | Su M.-C. HUANG-CHUN LIEN YUNG-MING JENG |
Issue Date: | 2005 | Journal Volume: | 224 | Journal Issue: | 1 | Start page/Pages: | 117-121 | Source: | Cancer Letters | Abstract: | The epidermal growth factor receptor (EGFR) is overexpressed in many epithelial tumors and plays an important role in the tumorigenesis of these tumors. Inhibitors of EGFR reduce the proliferation rate of cancers and are promising therapeutic agents of cancers. Recently, two studies have identified somatic mutations in the exons 18-21 of EGFR that were strongly correlated with robust clinical response to gefitinib treatment in patients with non-small cell lung cancer. To investigate whether EGFR mutation is involved in the tumorigenesis of hepatocellular carcinoma (HCC), we performed direct sequencing of exons 18-21 on 89 HCCs. No mutations causing amino acid changes or deletions were identified. The results indicate mutation of the kinase domain of EGFR does not play a significant role in the tumorigenesis of HCC and gefitinib is unlikely to be used as single-drug therapy for HCC. ? 2004 Elsevier Ireland Ltd. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-19444379632&doi=10.1016%2fj.canlet.2004.10.010&partnerID=40&md5=3e718ed6bb4bdd705302264000a29db9 https://scholars.lib.ntu.edu.tw/handle/123456789/473466 |
ISSN: | 0304-3835 | DOI: | 10.1016/j.canlet.2004.10.010 | SDG/Keyword: | epidermal growth factor receptor; amino acid sequence; article; carcinogenesis; controlled study; exon; gene deletion; gene expression; gene mutation; gene sequence; human; human tissue; liver cell carcinoma; priority journal; sequence analysis; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Base Sequence; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; DNA Mutational Analysis; DNA, Neoplasm; Exons; Female; Humans; Liver Neoplasms; Male; Middle Aged; Molecular Sequence Data; Point Mutation; Quinazolines; Receptor, Epidermal Growth Factor; Sequence Analysis, DNA |
Appears in Collections: | 病理學科所 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.