https://scholars.lib.ntu.edu.tw/handle/123456789/473503
標題: | Mutation of the DR5/TRAIL receptor 2 gene is infrequent in hepatocellular carcinoma | 作者: | YUNG-MING JENG Hsu H.-C. |
公開日期: | 2002 | 卷: | 181 | 期: | 2 | 起(迄)頁: | 205-208 | 來源出版物: | Cancer Letters | 摘要: | Chromosome 8p21-22 is a frequent site of loss of heterozygosity in many types of cancer, including hepatocellular carcinoma (HCC). Tumor necrosis factor-related apoptosis-inducing ligand-receptor 2 (TRAIL-R2/DR5), a member of tumor necrosis factor receptor family, is mapped to chromosome 8p21-22. Mutations of TRAIL-R2 have been detected in lung cancer, breast cancer, head and neck cancer, and non-Hodgkin's lymphoma. In this study, we analyzed the entire coding regions and all splicing sites of TRAIL-R2 in 40 HCCs and the death domain region in additional 60 HCCs. We could detect one point mutation in the death domain in only one HCC (1%). Our data suggest that somatic mutations of TRAIL-R2 gene do not play an important role in the carcinogenesis of HCC. ? 2002 Elsevier Science Ireland Ltd. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037178558&doi=10.1016%2fS0304-3835%2802%2900051-4&partnerID=40&md5=e8791622d45cefafcb8b44b1659e0a46 https://scholars.lib.ntu.edu.tw/handle/123456789/473503 |
ISSN: | 0304-3835 | DOI: | 10.1016/S0304-3835(02)00051-4 | SDG/關鍵字: | tumor necrosis factor; article; breast cancer; carcinogenesis; chromosome 8p; chromosome map; controlled study; gene mutation; head and neck cancer; heterozygosity; Hodgkin disease; human; human tissue; liver cell carcinoma; lung cancer; point mutation; priority journal; promoter region; protein domain; RNA splicing; Carcinoma, Hepatocellular; Genes, Tumor Suppressor; Humans; Liver Neoplasms; Mutation; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor |
顯示於: | 病理學科所 |
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