https://scholars.lib.ntu.edu.tw/handle/123456789/473503
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | YUNG-MING JENG | en_US |
dc.contributor.author | Hsu H.-C. | en_US |
dc.creator | Yung-Ming Jeng;Hsu H.-C. | - |
dc.date.accessioned | 2020-03-06T08:25:41Z | - |
dc.date.available | 2020-03-06T08:25:41Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037178558&doi=10.1016%2fS0304-3835%2802%2900051-4&partnerID=40&md5=e8791622d45cefafcb8b44b1659e0a46 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/473503 | - |
dc.description.abstract | Chromosome 8p21-22 is a frequent site of loss of heterozygosity in many types of cancer, including hepatocellular carcinoma (HCC). Tumor necrosis factor-related apoptosis-inducing ligand-receptor 2 (TRAIL-R2/DR5), a member of tumor necrosis factor receptor family, is mapped to chromosome 8p21-22. Mutations of TRAIL-R2 have been detected in lung cancer, breast cancer, head and neck cancer, and non-Hodgkin's lymphoma. In this study, we analyzed the entire coding regions and all splicing sites of TRAIL-R2 in 40 HCCs and the death domain region in additional 60 HCCs. We could detect one point mutation in the death domain in only one HCC (1%). Our data suggest that somatic mutations of TRAIL-R2 gene do not play an important role in the carcinogenesis of HCC. ? 2002 Elsevier Science Ireland Ltd. All rights reserved. | - |
dc.relation.ispartof | Cancer Letters | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | tumor necrosis factor; article; breast cancer; carcinogenesis; chromosome 8p; chromosome map; controlled study; gene mutation; head and neck cancer; heterozygosity; Hodgkin disease; human; human tissue; liver cell carcinoma; lung cancer; point mutation; priority journal; promoter region; protein domain; RNA splicing; Carcinoma, Hepatocellular; Genes, Tumor Suppressor; Humans; Liver Neoplasms; Mutation; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor | - |
dc.title | Mutation of the DR5/TRAIL receptor 2 gene is infrequent in hepatocellular carcinoma | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/S0304-3835(02)00051-4 | - |
dc.identifier.pmid | 12175536 | - |
dc.identifier.scopus | 2-s2.0-0037178558 | - |
dc.relation.pages | 205-208 | - |
dc.relation.journalvolume | 181 | - |
dc.relation.journalissue | 2 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.orcid | 0000-0002-3878-4491 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 病理學科所 |
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