https://scholars.lib.ntu.edu.tw/handle/123456789/473521
DC Field | Value | Language |
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dc.contributor.author | Hsu H.-C. | en_US |
dc.contributor.author | YUNG-MING JENG | en_US |
dc.contributor.author | TSUI-LIEN MAO | en_US |
dc.contributor.author | Chu J.-S. | en_US |
dc.contributor.author | Lai P.-L. | en_US |
dc.contributor.author | Peng S.-Y. | en_US |
dc.creator | Hsu H.-C.;Yung-Ming Jeng;Mao T.-L.;Chu J.-S.;Lai P.-L.;Peng S.-Y. | - |
dc.date.accessioned | 2020-03-06T08:25:44Z | - |
dc.date.available | 2020-03-06T08:25:44Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0002-9440 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034495080&doi=10.1016%2fS0002-9440%2810%2964590-7&partnerID=40&md5=cfd089f2836a0329bc9f70926200fe6f | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/473521 | - |
dc.description.abstract | To better understand the role of β-catenin mutation in hepatocellular carcinoma (HCC), we correlated the gene mutation with hepatitis virus B (HBV) and hepatitis virus C (HCV) status and the clinicopathological features in 366 patients with resected primary unifocal HCC. β-Catenin mutations were also analyzed in 55 patients with multifocal HCC (68 tumors). Of the whole series, 57 (13.1%) of 434 tumors examined had β-catenin mutations, 34 occurred at the serine/threonine residues of the GSK-3β region of β-catenin. Outside the GSK-3β phosphorylation site, codons 32 and 34 were two mutational hot spots (17 tumors). The non-HBV-related HCC that was predominantly HCV related had a higher frequency of mutation (P < 0.00001) and more frequent mutations at codon 45 than HBV-related HCC. HBV-related HCC had a younger mean age (P < 0.00001), and higher male-to-female ratio (P < 0.003) and positive familial history of HCC (P < 0.014). Among 366 unifocal HCCs selected for clinicopathological analysis, β-catenin mutations were associated with grade I (P = 0.005) and stage I and II HCC (P < 0.0001), and a better 5-year survival rate (P = 0.00003). These findings suggest mechanisms for β-catenin mutations differ between HBV-related and non-HBV-related HCCs, and that β-catenin mutation is a favorable prognostic factor related to low stage. β-Catenin mutation was associated with nuclear expression of the protein (P < 0.00001), but we failed to detect point or large fragment deletion mutation in 39 HCCs with nuclear β-catenin expression, presumably wild-type protein. HCCs expressing mutant nuclear β-catenin had a better 5-year survival rate (P < 0.007), suggesting that mutant and wild-type nuclear β-catenin proteins are not functionally equivalent and deserve more studies for further clarification. ? 2000 American Society for Investigative Pathology. | - |
dc.relation.ispartof | American Journal of Pathology | - |
dc.subject.other | beta catenin; article; cancer staging; controlled study; correlation function; gene deletion; gene mutation; Hepatitis B virus; human; human tissue; liver cell carcinoma; priority journal; prognosis; protein expression; sex ratio | - |
dc.subject.other | [SDGs]SDG3 | - |
dc.title | β-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis | en_US |
dc.type | journal article | - |
dc.identifier.doi | 10.1016/S0002-9440(10)64590-7 | - |
dc.identifier.pmid | 10980116 | - |
dc.identifier.scopus | 2-s2.0-0034495080 | - |
dc.relation.pages | 763-770 | - |
dc.relation.journalvolume | 157 | - |
dc.relation.journalissue | 3 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.orcid | 0000-0002-3878-4491 | - |
crisitem.author.orcid | 0000-0002-0159-3691 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
Appears in Collections: | 病理學科所 |
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