https://scholars.lib.ntu.edu.tw/handle/123456789/473545
DC 欄位 | 值 | 語言 |
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dc.contributor.author | I-CHUN CHEN | en_US |
dc.contributor.author | Chang Y.-C. | en_US |
dc.contributor.author | YEN-SHEN LU | en_US |
dc.contributor.author | KUEI-PIN CHUNG | en_US |
dc.contributor.author | CHIUN-SHENG HUANG | en_US |
dc.contributor.author | TZU-PIN LU | en_US |
dc.contributor.author | WEN-HUNG KUO | en_US |
dc.contributor.author | Wang M.-Y. | en_US |
dc.contributor.author | KUAN-TING KUO | en_US |
dc.contributor.author | Wu P.-F. | en_US |
dc.contributor.author | Hsueh T.-H. | en_US |
dc.contributor.author | Shen C.-Y. | en_US |
dc.contributor.author | CHING-HUNG LIN | en_US |
dc.contributor.author | ANN-LII CHENG | en_US |
dc.creator | Chen I.-C.;Chang Y.-C.;Lu Y.-S.;Chung K.-P.;Huang C.-S.;Lu T.-P.;Kuo W.-H.;Wang M.-Y.;Kuan-Ting Kuo;Wu P.-F.;Hsueh T.-H.;Shen C.-Y.;Lin C.-H.;Cheng A.-L. | - |
dc.date.accessioned | 2020-03-07T06:42:07Z | - |
dc.date.available | 2020-03-07T06:42:07Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84958787432&doi=10.1038%2fsrep21374&partnerID=40&md5=8f404e2e2c29f3a1f276726f20bef940 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/473545 | - |
dc.description.abstract | Liver kinase B1 (LKB1) is a tumor suppressor, and its loss might lead to activation of the mammalian target of rapamycin (mTOR) and tumorigenesis. This study aimed to determine the clinical relevance of LKB1 gene and protein expression in breast cancer patients. LKB1 protein expression was evaluated using immunohistochemistry in tumors from early breast cancer patients in two Taiwanese medical centers. Data on LKB1 gene expression were obtained from the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) data set. The correlations between LKB1 expression, clinicopathologic factors, and patient outcome were analyzed. LKB1 expression was significantly associated with estrogen receptor (ER) expression in 2 of the 4 cohorts, but not with other clinicopathologic factors. LKB1 expression was not a predictor for relapse-free survival, overall survival (OS), or breast cancer-specific survival. In a subgroup analysis of the two Taiwanese cohorts, high LKB1 protein expression was predictive of high OS in human epidermal growth factor receptor 2 (HER2)-positive breast cancer patients (P = 0.013). Our study results indicate that LKB1 expression is not prognostic in the whole population of breast cancer patients, but it is a potential predictor of OS in the subset of HER2-positive patients. | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.ispartof | Scientific Reports | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | epidermal growth factor receptor 2; ERBB2 protein, human; protein serine threonine kinase; STK11 protein, human; adult; aged; biosynthesis; breast tumor; cancer staging; disease free survival; female; gene expression regulation; genetics; human; middle aged; pathology; prognosis; tumor recurrence; Adult; Aged; Breast Neoplasms; Disease-Free Survival; Female; Gene Expression Regulation, Neoplastic; Humans; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Protein-Serine-Threonine Kinases; Receptor, ErbB-2 | - |
dc.title | Clinical Relevance of Liver Kinase B1(LKB1) Protein and Gene Expression in Breast Cancer | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/srep21374 | - |
dc.identifier.pmid | 26877155 | - |
dc.identifier.scopus | 2-s2.0-84958787432 | - |
dc.relation.pages | 21374 | - |
dc.relation.journalvolume | 6 | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.dept | Clinical Trial Center | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Institute of Health Data Analytics and Statistics | - |
crisitem.author.dept | Public Health | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Medical Oncology-NTUCC | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.orcid | 0000-0001-7461-1291 | - |
crisitem.author.orcid | 0000-0003-1916-8068 | - |
crisitem.author.orcid | 0000-0002-6557-211X | - |
crisitem.author.orcid | 0000-0003-3697-0386 | - |
crisitem.author.orcid | 0000-0002-9881-4605 | - |
crisitem.author.orcid | 0000-0002-3657-1652 | - |
crisitem.author.orcid | 0000-0003-2403-4056 | - |
crisitem.author.orcid | 0000-0002-9152-6512 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 病理學科所 |
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