https://scholars.lib.ntu.edu.tw/handle/123456789/473548
標題: | TP53 Mutational Analysis Enhances the Prognostic Accuracy of IHC4 and PAM50 Assays | 作者: | CHING-HUNG LIN Chen I.-C. CHIUN-SHENG HUANG Hu F.-C. WEN-HUNG KUO KUAN-TING KUO Wang C.-C. Wu P.-F. DWANG-YING CHANG Wang M.-Y. Chang C.-H. WEI-WU CHEN YEN-SHEN LU ANN-LII CHENG |
公開日期: | 2015 | 出版社: | Nature Publishing Group | 卷: | 5 | 起(迄)頁: | 17879 | 來源出版物: | Scientific Reports | 摘要: | IHC4 and PAM50 assays have been shown to provide additional prognostic information for patients with early breast cancer. We evaluated whether incorporating TP53 mutation analysis can further enhance their prognostic accuracy. We examined TP53 mutation and the IHC4 score in tumors of 605 patients diagnosed with stage I-III breast cancer at National Taiwan University Hospital (the NTUH cohort). We obtained information regarding TP53 mutation and PAM50 subtypes in 699 tumors from the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) cohort. We found that TP53 mutation was significantly associated with high-risk IHC4 group and with luminal B, HER2-enriched, and basallike subtypes. Despite the strong associations, TP53 mutation independently predicted shorter relapsefree survival (hazard ratio [HR] = 1.63, P = 0.007) in the NTUH cohort and shorter breast cancer-specific survival (HR = 2.35, P = <0.001) in the METABRIC cohort. TP53 mutational analysis added significant prognostic information in addition to the IHC4 score ( δ LR-χ2 = 8.61, P = 0.002) in the NTUH cohort and the PAM50 subtypes (δ LR-χ2 = 18.9, P = <0.001) in the METABRIC cohort. We conclude that incorporating TP53 mutation analysis can enhance the prognostic accuracy of the IHC4 and PAM50 assays. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84950142353&doi=10.1038%2fsrep17879&partnerID=40&md5=2ad1e603bb919b2a2671a1dfe4f47d77 https://scholars.lib.ntu.edu.tw/handle/123456789/473548 |
ISSN: | 2045-2322 | DOI: | 10.1038/srep17879 | SDG/關鍵字: | protein p53; tumor marker; adult; aged; Breast Neoplasms; cancer grading; cancer staging; cohort analysis; dna mutational analysis; female; gene expression profiling; genetics; human; immunohistochemistry; Kaplan Meier method; metabolism; middle aged; mortality; mutation; procedures; prognosis; Taiwan; very elderly; young adult; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Cohort Studies; DNA Mutational Analysis; Female; Gene Expression Profiling; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Middle Aged; Mutation; Neoplasm Grading; Neoplasm Staging; Prognosis; Taiwan; Tumor Suppressor Protein p53; Young Adult |
顯示於: | 病理學科所 |
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