https://scholars.lib.ntu.edu.tw/handle/123456789/473602
Title: | Downregulation of BRG-1 repressed expression of CD44s in cervical neuroendocrine carcinoma and adenocarcinoma | Authors: | KUAN-TING KUO Liang C.-W. Hsiao C.-H. CHING-HUNG LIN CHI-AN CHEN BOR-CHING SHEU Lin M.-C. |
Issue Date: | 2006 | Journal Volume: | 19 | Journal Issue: | 12 | Start page/Pages: | 1570-1577 | Source: | Modern Pathology | Abstract: | Neuroendocrine carcinomas of the uterine cervix are rare tumors with early metastases, highly aggressive clinical behavior, and poor clinical outcome. Several adhesion molecules like cadherins have been tested in an attempt to explain their unique characteristics. Cluster differentiation 44 (CD44) is a widely expressed cell surface glycoprotein that serves as an adhesion molecule in cell-to-substrate and cell-to-cell interaction. We have examined the expression of the standard CD44 (CD44s) by immunohistochemical stains in the paraffin-embedded cervical neoplasm tissue of 17 cases of primary cervical neuroendocrine carcinoma, 28 cases of cervical adenocarcinoma, and 50 cases of cervical squamous cell carcinoma. Loss of CD44s expression was found in 16 of 17 neuroendocrine carcinomas, 14 of 28 adenocarcinomas, and three of 50 squamous cell carcinomas. The differences were statistically significant. We also examined immunohistochemically the expression of the BRG-1 subunit of the SWI-SNF complex, which has been reported to regulate the expression of CD44 in all cases. Loss of BRG-1 expression was observed in 12/16, 6/14, and 1/3 CD44s-negative neuroendocrine carcinomas, adenocarcinomas, and squamous cell carcinomas, respectively. This study suggests that loss of the CD44s molecule may imply special biological behaviors of cervical neuroendocrine carcinomas, and loss of expression of BRG-1 may contribute to this. ? 2006 USCAP, Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33751235842&doi=10.1038%2fmodpathol.3800687&partnerID=40&md5=5377aec28396e57d631c7381caa86f73 https://scholars.lib.ntu.edu.tw/handle/123456789/473602 |
ISSN: | 0893-3952 | DOI: | 10.1038/modpathol.3800687 | SDG/Keyword: | adenosine triphosphatase; cadherin; cell adhesion molecule; cell surface protein; Hermes antigen; paraffin; protein brg 1; protein snf; protein subunit; protein SWI; unclassified drug; adenocarcinoma; adult; article; cancer diagnosis; cell adhesion; cell interaction; clinical feature; controlled study; down regulation; gene expression regulation; gene loss; gene repression; histopathology; human; human tissue; immunohistochemistry; major clinical study; metastasis; neuroendocrine tumor; priority journal; protein expression; squamous cell carcinoma; statistical significance; uterine cervix carcinoma; Adult; Antigens, CD44; Carcinoma, Neuroendocrine; Carcinoma, Squamous Cell; DNA Helicases; Down-Regulation; Female; Humans; Immunohistochemistry; Middle Aged; Nuclear Proteins; Transcription Factors; Tumor Markers, Biological; Uterine Cervical Neoplasms |
Appears in Collections: | 病理學科所 |
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