https://scholars.lib.ntu.edu.tw/handle/123456789/473625
標題: | Loss of ARID1A expression correlates with stages of tumor progression in uterine endometrioid carcinoma | 作者: | TSUI-LIEN MAO Ardighieri L. Ayhan A. KUAN-TING KUO Wu C.-H. Wang T.-L. Shih I.-M. |
公開日期: | 2013 | 卷: | 37 | 期: | 9 | 起(迄)頁: | 1342-1348 | 來源出版物: | American Journal of Surgical Pathology | 摘要: | ARID1A is a recently identified tumor suppressor that functions in chromatin remodeling. Inactivating mutations of ARID1A and loss of its expression most frequently occur in ovarian clear cell carcinoma, ovarian endometrioid carcinoma, and uterine endometrioid carcinoma. In this study, we performed a detailed immunostaining analysis of ARID1A in 246 cases including benign endometrium and endometrioid carcinoma at different stages of progression. Special attention was paid to recording intratumoral heterogeneity of clonal loss of ARID1A immunoreactivity. All normal endometria (n=51) and endometrial polyps (n=14) retained ARID1A expression. Among complex atypical hyperplasias (n=38), 16% exhibited clonal loss of ARID1A, but none showed complete loss. Among low-grade endometrioid carcinomas (n=88), 25% exhibited complete loss and 24% exhibited clonal loss. In contrast, 44% of high-grade endometrioid carcinomas (n=55) showed complete loss of ARID1A, and 9% exhibited clonal loss. We found that 19 high-grade carcinomas also contained concurrent low-grade carcinomas. In the high-grade areas, 63% exhibited complete loss and 11% exhibited clonal loss, whereas in the low-grade areas, 37% exhibited complete loss and 42% clonal loss. In 5 of these 19 cases, progressive loss of ARID1A from retention or clonal loss to complete loss was observed between the low-grade and high-grade areas. Overall, the percentage of complete ARID1A loss increased from 0% in complex atypical hyperplasia, to 25% in low-grade endometrioid carcinoma, to 44% in high-grade endometrioid carcinoma. These findings suggest that loss of ARID1A expression, presumably due to mutation, plays an important role in tumor progression of uterine endometrioid carcinoma. Copyright ? 2013 by Lippincott Williams & Wilkins. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84884507473&doi=10.1097%2fPAS.0b013e3182889dc3&partnerID=40&md5=e80b104d46c804029d93479ed4d32309 https://scholars.lib.ntu.edu.tw/handle/123456789/473625 |
ISSN: | 0147-5185 | DOI: | 10.1097/PAS.0b013e3182889dc3 | SDG/關鍵字: | ARID1A protein, human; nuclear protein; transcription factor; tumor marker; adult; aged; article; biopsy; cancer grading; cancer staging; case control study; chemistry; comparative study; disease course; down regulation; endometrioid carcinoma; female; human; immunohistochemistry; middle aged; pathology; predictive value; time; uterus cancer; very elderly; Adult; Aged; Aged, 80 and over; Biopsy; Carcinoma, Endometrioid; Case-Control Studies; Disease Progression; Down-Regulation; Female; Humans; Immunohistochemistry; Middle Aged; Neoplasm Grading; Neoplasm Staging; Nuclear Proteins; Predictive Value of Tests; Time Factors; Transcription Factors; Tumor Markers, Biological; Uterine Neoplasms |
顯示於: | 病理學科所 |
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