https://scholars.lib.ntu.edu.tw/handle/123456789/473741
標題: | A clinicopathological analysis of 153 acral melanomas and the relevance of mechanical stress | 作者: | YI-SHUAN SHEEN YI-HUA LIAO Lin M.-H. JAU-SHIUH CHEN JAU-YU LIAU Tseng Y.-J. Lee C.-H. YIH-LEONG CHANG CHIA-YU CHU |
公開日期: | 2017 | 出版社: | Nature Publishing Group | 卷: | 7 | 期: | 1 | 起(迄)頁: | 5564 | 來源出版物: | Scientific Reports | 摘要: | The pathogenesis of melanomas emerging in plantar surfaces remains unclear; however, mechanical stress has been reported to increase the formation of melanomas. In this study, we conducted a multicenter retrospective analysis of 153 acral melanomas diagnosed between 2000 and 2015 in Taiwan. The male-to-female ratio of the patients in question was 1:1.28, and the mean age at diagnosis was 68 years. We examined whether melanomas which developed in different areas of the patients' soles differed in their associations with various clinicopathological characteristics and survival. Testing by goodness of fit indicated that stress-bearing areas were significantly more conducive to the generation of melanomas than non-stress-bearing areas (P < 0.0001). More specifically, compared to the arch, the rear of the foot and front of the foot were significantly more conducive to the generation of melanomas (P < 0.0001 and P < 0.0001, respectively). The distribution pattern was not associated with differences in age, gender, right/left foot involvement, ulceration, mitosis, lymph node metastasis, tumor thickness, or stage. The overall, distant metastasis-free, and recurrence-free survival rates did not differ significantly between the stress-bearing and non-stress-bearing areas. Furthermore, while acral melanomas tended to develop on stress-bearing areas, the distribution pattern was not associated with the prognostic index or survival. ? 2017 The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025153446&doi=10.1038%2fs41598-017-05809-9&partnerID=40&md5=afb354ea80233f455af4b70f55fe2a49 https://scholars.lib.ntu.edu.tw/handle/123456789/473741 |
ISSN: | 2045-2322 | DOI: | 10.1038/s41598-017-05809-9 | SDG/關鍵字: | adult; aged; clinical trial; disease free survival; female; foot; human; male; mechanical stress; melanoma; middle aged; mortality; multicenter study; pathology; retrospective study; skin tumor; survival rate; Taiwan; tumor recurrence; very elderly; Adult; Aged; Aged, 80 and over; Disease-Free Survival; Female; Foot; Humans; Male; Melanoma; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Skin Neoplasms; Stress, Mechanical; Survival Rate; Taiwan |
顯示於: | 病理學科所 |
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