https://scholars.lib.ntu.edu.tw/handle/123456789/473801
標題: | The impact of perineural invasion and/or lymphovascular invasion on the survival of early-stage oral squamous cell carcinoma patients | 作者: | TSENG-CHENG CHEN CHENG-PING WANG JENG-YUH KO TSUNG-LIN YANG Hsu C.-W. Yeh K.-A. YIH-LEONG CHANG PEI-JEN LOU |
公開日期: | 2013 | 卷: | 20 | 期: | 7 | 起(迄)頁: | 2388-2395 | 來源出版物: | Annals of Surgical Oncology | 摘要: | Background: For early-stage oral squamous cell carcinoma (OSCC) patients, the impact of perineural invasion (PNI) and lymphovascular invasion (LVI) on disease control and survival has not been clarified. Methods: The medical records of all early-stage OSCC patients who underwent curative surgery between 2004 and 2009 were reviewed. Results: A total of 442 early stage patients were included in this study. There were 360 patients in group A (without PNI or LVI) and 82 patients in group B (with PNI and/or LVI). Between groups A and B patients, there were no significant differences in the 5-year disease-free survival (73.8 vs 68.7 %, p = 0.48) and overall survival (90.9 vs 86.1 %, p = 0.25). Between groups A and B patients without postoperative radiotherapy (PORT), there were no significant differences in the 5-year disease-free survival (73.8 vs 70.2 %, p = 0.51) and overall survival (90.9 vs 85.2 %, p = 0.18). Between group B patients with and without PORT, there was no significant difference in either the disease-free survival (61.1 vs 70.2 %, p = 0.98) and overall survival (88.9 vs 85.2 %, p = 0.64). Multivariate analyses revealed that PNI, LVI, and PORT could not provide significant effect on treatment outcome. Conclusions: PNI and LVI were not significant risk factors for the disease control and overall survival for early stage OSCC patients. Furthermore, PORT could not provide an additional benefit for the disease control and overall survival for stages I and II OSCC patients with PNI and/or LVI. ? 2013 Society of Surgical Oncology. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84878887723&doi=10.1245%2fs10434-013-2870-4&partnerID=40&md5=a0390875fccff1f68411926d2d0ff8e0 https://scholars.lib.ntu.edu.tw/handle/123456789/473801 |
ISSN: | 1068-9265 | DOI: | 10.1245/s10434-013-2870-4 | SDG/關鍵字: | adult; aged; cancer control; cancer patient; cancer radiotherapy; cancer staging; cancer surgery; cancer survival; controlled study; disease free survival; early cancer; female; human; lymph vessel metastasis; major clinical study; male; medical record review; mouth squamous cell carcinoma; overall survival; perineural invasion; postoperative care; review; treatment outcome; Adult; Aged; Aged, 80 and over; Blood Vessels; Carcinoma, Squamous Cell; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Lymphatic Vessels; Male; Middle Aged; Mouth Neoplasms; Multivariate Analysis; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Peripheral Nerves; Proportional Hazards Models; Radiotherapy, Adjuvant; Retrospective Studies |
顯示於: | 病理學科所 |
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