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  4. New aspects in clinicopathologic and oncogene studies of 23 pulmonary lymphoepithelioma-like carcinomas
 
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New aspects in clinicopathologic and oncogene studies of 23 pulmonary lymphoepithelioma-like carcinomas

Journal
American Journal of Surgical Pathology
Journal Volume
26
Journal Issue
6
Pages
715-723
Date Issued
2002
Author(s)
YIH-LEONG CHANG  
CHEN-TU WU  
JIN-YUAN SHIH  
Lee Y.-C.
DOI
10.1097/00000478-200206000-00004
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036098103&doi=10.1097%2f00000478-200206000-00004&partnerID=40&md5=0ccc39f95931dfb66c6142f3a05ce042
https://scholars.lib.ntu.edu.tw/handle/123456789/473939
Abstract
Lymphoepithelioma-like carcinoma, an uncommon epithelial tumor, has been described as being closely associated with Epstein-Barr virus (EBV) infection in many organs, especially the nasopharynx. We experienced 23 cases of lympho-epithelioma-like carcinoma arising in the lung from 2498 lung cancer patients in the Cancer Registry of our hospital. Seven patients were male and 16 were female. All patients were Chinese. Their ages ranged from 42 to 80 years. Six patients were smokers and 17 were nonsmokers. The tumor sizes ranged from 1.2 to 11.0 cm. All tumors showed the typical syncytial growth pattern of undifferentiated epithelial cells with a significant CD8+ T-lymphocyte reaction. EBV serology revealed prior infection in all 15 serum-available patients, all of whom were also found by in situ hybridization to have the virus genome. In addition, the higher the EBV serology titer, the larger the tumor size and the higher the staging would be. EBV viral capsid antigen IgG level remained elevated despite response to therapy. Nearly all cases had bcl-2 oncoprotein expression, but the detection rate of latent membrane protein-1, p53, and c-erb B-2 expression was extremely low. The encouraging chemotherapy response for advanced stage disease is also discussed.
SDGs

[SDGs]SDG3

Other Subjects
CD8 antigen; immunoglobulin G antibody; latent membrane protein 1; oncoprotein; protein bcl 2; protein p53; virus capsid antigen; adult; aged; antibody titer; article; cancer chemotherapy; cancer growth; cancer registry; cancer size; cancer staging; cell differentiation; Chinese; clinical article; clinical feature; controlled study; disease association; drug response; Epstein Barr virus; female; histopathology; human; human tissue; in situ hybridization; lung alveolus epithelium; lung carcinoma; lymphoepithelioma; male; oncogene c erb; protein expression; serodiagnosis; smoking; syncytium; T lymphocyte subpopulation; tumor suppressor gene; virus carcinogenesis; virus infection; Adult; Aged; Aged, 80 and over; Antigens, Viral; Capsid Proteins; Carcinoma; CD8-Positive T-Lymphocytes; Cell Count; Female; Herpesviridae Infections; Herpesvirus 4, Human; Humans; Immunohistochemistry; In Situ Hybridization; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Proto-Oncogene Proteins c-bcl-2; RNA, Viral; Tumor Suppressor Protein p53
Type
journal article

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