https://scholars.lib.ntu.edu.tw/handle/123456789/473971
Title: | Vascular pathology of malignant cervical lymphadenopathy: Qualitative and quantitative assessment with power doppler ultrasound | Authors: | Wu C.-H. Hsu M.-M. YIH-LEONG CHANG FON-JOU HSIEH |
Keywords: | Angiogenesis; Lymphadenopathy; Power Doppler study; Ultrasound | Issue Date: | 1998 | Journal Volume: | 83 | Journal Issue: | 6 | Start page/Pages: | 1189-1196 | Source: | Cancer | Abstract: | BACKGROUND. Malignant vascular pathology has traditionally been studied with invasive angiography or in vitro immunohistochemistry. The objective of this study was to investigate the vascular patterns and vascular density of benign and malignant cervical lymphadenopathy using power Doppler ultrasound combined with a computed quantitative image processing system. METHODS. Investigations of 189 cervical lymph node lesions were undertaken prospectively using a 5-10 MHz linear array transducer in power mode. The types of vascular patterns displayed with power Doppler ultrasound, after sweep-scanning over the whole lymph node, were classified as hilar, spotted, peripheral, or mixed. Quantitative assessment of vascularity was made by sampling three parallel planes of each lymph node. A computed image processing system automatically calculated the density of Vascular signals (called the 'vascularity index' in this study) within the lymph node plane. RESULTS. Malignant lymph node lesions were shown to have higher vascularity indices (0.169 ± 0.147, P < 0.01). The vascular patterns of benign lesions were mostly of avascular or hilar type (in 83% of cases). Malignant lesions were characterized by patterns of mixed (47%), spotted (20%), or peripheral type (11%). When vascular pattern (nonhilar type) and vascularity index (maximum ?0.09) were combined, the specificity for diagnosing malignant lymphadenopathy was as high as 97%. Variance in rumor vascularity was noted in both the benign and malignant groups. CONCLUSIONS. Power Doppler ultrasound combined with a computed image processing system provided an objective tool for assessing tumor vascularity quantitatively. Using this modality, the vascular pathology of malignant lymphadenopathy was found to be characterized by higher vascular density and aberrant vascular patterns. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032530230&doi=10.1002%2f%28SICI%291097-0142%2819980915%2983%3a6%3c1189%3a%3aAID-CNCR19%3e3.0.CO%3b2-1&partnerID=40&md5=69e194b0652ba5d8fd8f57c0445ba286 https://scholars.lib.ntu.edu.tw/handle/123456789/473971 |
ISSN: | 0008-543X | DOI: | 10.1002/(SICI)1097-0142(19980915)83:6<1189 | SDG/Keyword: | adolescent; adult; aged; angiogenesis; article; cervical lymph node; color ultrasound flowmetry; diagnostic accuracy; differential diagnosis; female; head and neck cancer; human; lymphadenopathy; lymphoma; major clinical study; male; priority journal; squamous cell carcinoma; tuberculosis; tumor blood flow; Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Female; Humans; Lymph Nodes; Lymphatic Diseases; Lymphatic Metastasis; Male; Middle Aged; Neck; Prospective Studies; Sensitivity and Specificity; Ultrasonography, Doppler, Color |
Appears in Collections: | 病理學科所 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.