https://scholars.lib.ntu.edu.tw/handle/123456789/473971
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wu C.-H. | en_US |
dc.contributor.author | Hsu M.-M. | en_US |
dc.contributor.author | YIH-LEONG CHANG | en_US |
dc.contributor.author | FON-JOU HSIEH | en_US |
dc.creator | Wu C.-H.;Hsu M.-M.;Yih-Leong Chang;Hsieh F.-J. | - |
dc.date.accessioned | 2020-03-07T06:57:15Z | - |
dc.date.available | 2020-03-07T06:57:15Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0008-543X | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032530230&doi=10.1002%2f%28SICI%291097-0142%2819980915%2983%3a6%3c1189%3a%3aAID-CNCR19%3e3.0.CO%3b2-1&partnerID=40&md5=69e194b0652ba5d8fd8f57c0445ba286 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/473971 | - |
dc.description.abstract | BACKGROUND. Malignant vascular pathology has traditionally been studied with invasive angiography or in vitro immunohistochemistry. The objective of this study was to investigate the vascular patterns and vascular density of benign and malignant cervical lymphadenopathy using power Doppler ultrasound combined with a computed quantitative image processing system. METHODS. Investigations of 189 cervical lymph node lesions were undertaken prospectively using a 5-10 MHz linear array transducer in power mode. The types of vascular patterns displayed with power Doppler ultrasound, after sweep-scanning over the whole lymph node, were classified as hilar, spotted, peripheral, or mixed. Quantitative assessment of vascularity was made by sampling three parallel planes of each lymph node. A computed image processing system automatically calculated the density of Vascular signals (called the 'vascularity index' in this study) within the lymph node plane. RESULTS. Malignant lymph node lesions were shown to have higher vascularity indices (0.169 ± 0.147, P < 0.01). The vascular patterns of benign lesions were mostly of avascular or hilar type (in 83% of cases). Malignant lesions were characterized by patterns of mixed (47%), spotted (20%), or peripheral type (11%). When vascular pattern (nonhilar type) and vascularity index (maximum ?0.09) were combined, the specificity for diagnosing malignant lymphadenopathy was as high as 97%. Variance in rumor vascularity was noted in both the benign and malignant groups. CONCLUSIONS. Power Doppler ultrasound combined with a computed image processing system provided an objective tool for assessing tumor vascularity quantitatively. Using this modality, the vascular pathology of malignant lymphadenopathy was found to be characterized by higher vascular density and aberrant vascular patterns. | en_US |
dc.relation.ispartof | Cancer | en_US |
dc.subject | Angiogenesis; Lymphadenopathy; Power Doppler study; Ultrasound | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | adolescent; adult; aged; angiogenesis; article; cervical lymph node; color ultrasound flowmetry; diagnostic accuracy; differential diagnosis; female; head and neck cancer; human; lymphadenopathy; lymphoma; major clinical study; male; priority journal; squamous cell carcinoma; tuberculosis; tumor blood flow; Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Female; Humans; Lymph Nodes; Lymphatic Diseases; Lymphatic Metastasis; Male; Middle Aged; Neck; Prospective Studies; Sensitivity and Specificity; Ultrasonography, Doppler, Color | - |
dc.title | Vascular pathology of malignant cervical lymphadenopathy: Qualitative and quantitative assessment with power doppler ultrasound | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/(SICI)1097-0142(19980915)83:6<1189 | - |
dc.identifier.pmid | 9740085 | - |
dc.identifier.scopus | 2-s2.0-0032530230 | - |
dc.relation.pages | 1189-1196 | en_US |
dc.relation.journalvolume | 83 | en_US |
dc.relation.journalissue | 6 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Pathology-NTUCC | - |
crisitem.author.orcid | 0000-0001-5309-0554 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
顯示於: | 病理學科所 |
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