https://scholars.lib.ntu.edu.tw/handle/123456789/474117
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | NAI-CHEN CHENG | en_US |
dc.contributor.author | Yu Y.-C. | en_US |
dc.contributor.author | HAO-CHIH TAI | en_US |
dc.contributor.author | PO-REN HSUEH | en_US |
dc.contributor.author | SHAN-CHWEN CHANG | en_US |
dc.contributor.author | Lai S.-Y. | en_US |
dc.contributor.author | Yi W.-C. | en_US |
dc.contributor.author | CHI-TAI FANG | en_US |
dc.creator | Nai-Chen Cheng;Yu Y.-C.;Tai H.-C.;Hsueh P.-R.;Chang S.-C.;Lai S.-Y.;Yi W.-C.;Fang C.-T. | - |
dc.date.accessioned | 2020-03-09T04:24:10Z | - |
dc.date.available | 2020-03-09T04:24:10Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1058-4838 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84866128716&doi=10.1093%2fcid%2fcis565&partnerID=40&md5=2c5f5ec8656c6cd3cb503f21ef5ca3c7 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/474117 | - |
dc.description.abstract | Background.Necrotizing fasciitis (NF) is a rapidly progressive, life-threatening soft-tissue infection that is traditionally caused by group A Streptococcus (GAS) or mixed aerobic/anaerobic bacteria. Monomicrobial Klebsiella pneumoniae NF (KP-NF) has been reported since 1996 but has not yet been systematically studied.Methods.We retrospectively studied consecutive NF cases treated at a university hospital in Taiwan during 1997-2010 and investigated the clinical characteristics and outcomes associated with monomicrobial KP-NF, using monomicrobial GAS-NF as a reference. We also analyzed the virulence gene profiles of the isolated K. pneumoniae strains.Results.Of 134 NF cases, 88 were monomicrobial, of which the most common pathogens were GAS (n = 16) and K. pneumoniae (n = 15). Monomicrobial KP-NF entailed a moderate risk of limb loss (20 vs 25; P = 1.000) and high mortality (47 vs 19; P =. 135), and it was more likely to involve bacteremia (80 vs 31; P =. 011), concomitant distant abscesses (27 vs 0; P =. 043), and underlying immunocompromising conditions (100 vs 63; P =. 018), compared with GAS-NF. The isolated K. pneumoniae strains (n = 10) were of capsular polysaccharides genotype K1 (n = 4), K54/K20/K5 (n = 4), K2 (n = 1), and K16 (n = 1). All strains carried rmpA, iucABCDiutA, and iroA. Genotype K1 strains had a significantly higher risk of concomitant distant abscesses, compared with non-K1 strains (75 vs 0; P =. 033).Conclusions.K. pneumoniae has become a common pathogen of monomicrobial NF in Taiwan. Physicians treating patients with monomicrobial KP-NF should be aware of the risk of concomitant distant abscesses, particularly in cases caused by genotype K1. ? The Author 2012. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. | - |
dc.relation.ispartof | Clinical Infectious Diseases | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | amikacin; amoxicillin plus clavulanic acid; ampicillin; cefazolin; cefepime; cefotaxime; cefoxitin; ceftriaxone; ciprofloxacin; clavulanic acid; flomoxef; gentamicin; imipenem; meropenem; oxacillin; polysaccharide; sulbactam; ticarcillin; tobramycin; abscess; adult; aged; antibiotic resistance; antibiotic sensitivity; article; bacteremia; bacterial virulence; below knee amputation; debridement; fasciotomy; female; genotype; group A streptococcal infection; human; immunocompromised patient; incision; Klebsiella pneumoniae; Klebsiella pneumoniae infection; major clinical study; male; mortality; necrotizing fasciitis; nonhuman; nucleotide sequence; priority journal; retrospective study; split thickness skin graft; Streptococcus group A; surgical drainage; Taiwan; Adult; Aged; DNA, Bacterial; Fasciitis, Necrotizing; Female; Hospitals, University; Humans; Klebsiella Infections; Klebsiella pneumoniae; Male; Middle Aged; Molecular Sequence Data; Prevalence; Retrospective Studies; Sequence Analysis, DNA; Streptococcal Infections; Streptococcus pyogenes; Survival Analysis; Taiwan; Treatment Outcome; Virulence Factors | - |
dc.title | Recent trend of necrotizing fasciitis in taiwan: Focus on monomicrobial Klebsiella pneumoniae necrotizing fasciitis | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1093/cid/cis565 | - |
dc.identifier.pmid | 22715175 | - |
dc.identifier.scopus | 2-s2.0-84866128716 | - |
dc.relation.pages | 930-939 | - |
dc.relation.journalvolume | 55 | - |
dc.relation.journalissue | 7 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Office of the Vice President | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Public Health | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-4071-5628 | - |
crisitem.author.orcid | 0000-0001-8155-3077 | - |
crisitem.author.orcid | 0000-0002-7502-9225 | - |
crisitem.author.orcid | 0000-0001-6505-4139 | - |
crisitem.author.orcid | 0000-0002-7380-1699 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Administrative Unit | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
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