|Title:||Heart Transplantation under Mechanical Circulatory Support for Acute Fulminant Myocarditis with Cardiogenic Shock 10 Years' Experience of a Single Center||Authors:||Ting M.
|Issue Date:||2016||Publisher:||Elsevier USA||Journal Volume:||48||Journal Issue:||3||Start page/Pages:||951-955||Source:||Transplantation Proceedings||Abstract:||
Background Acute fulminant myocarditis with intractable cardiogenic shock is a fatal condition; its only therapeutic option is mechanical circulatory support. The use of mechanical circulatory support, either extracorporeal membrane oxygenation (ECMO) or a ventricular assist device (VAD), serves as a bridge to recovery or as a bridge to transplantation. Objectives The aim of this research was to advance our understanding of the outcome of heart transplantation under mechanical support for acute myocarditis. Two groups of patients were compared: those recovered without undergoing transplantation and those who underwent transplantation. Methods We reviewed 134 patients experiencing acute myocarditis who required mechanical circulatory support (including ECMO and/or VAD) in our institute between 1994 and 2014. Demographic data, clinical characteristics, support duration, and outcome of individuals were retrospectively analyzed. Results Patients taking part in this study were aged from 1 month to 70 years, with an average age of 28 years. The transplantation-free survival rate in adults was 54%. A total of 6 adult patients receive a heart transplant under ECMO/left VAD; 2 of these patients died of uncontrolled sepsis after the heart transplantation. The duration of mechanical support ranged from 10 to 130 days (average, 41 days). Conclusions Mechanical circulatory support in patients with acute myocarditis proved to be effective. Approximately one half of all adult patients in this study experienced myocardium recovery under mechanical support, with only 5% undergoing a successful heart transplantation. In terms of patients who survived after heart transplantation, the mid-term and long-term outcomes are favorable. ? 2016 Elsevier Inc.
|ISSN:||0041-1345||DOI:||10.1016/j.transproceed.2015.12.109||metadata.dc.subject.other:||acute disease; acute fulminant myocarditis; adolescent; adult; aged; Article; assisted circulation; brain death; cardiogenic shock; child; disease association; extracorporeal oxygenation; female; forward heart failure; heart transplantation; human; infant; major clinical study; male; myocarditis; priority journal; resuscitation; sepsis; survival rate; treatment duration; ventricular assist device; acute disease; complication; forecasting; heart assist device; heart transplantation; middle aged; myocarditis; procedures; retrospective study; Shock, Cardiogenic; Acute Disease; Adult; Extracorporeal Membrane Oxygenation; Female; Forecasting; Heart Transplantation; Heart-Assist Devices; Humans; Male; Middle Aged; Myocarditis; Retrospective Studies; Shock, Cardiogenic
|Appears in Collections:||醫學系|
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