https://scholars.lib.ntu.edu.tw/handle/123456789/474223
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHUN-FU LAI | en_US |
dc.contributor.author | VIN-CENT WU | en_US |
dc.contributor.author | TAO-MIN HUANG | en_US |
dc.contributor.author | YU-CHANG YEH | en_US |
dc.contributor.author | KUO-CHUAN WANG | en_US |
dc.contributor.author | YIN-YI HAN | en_US |
dc.contributor.author | YU-FENG LIN | en_US |
dc.contributor.author | Jhuang Y.-J. | en_US |
dc.contributor.author | CHIA-TER CHAO | en_US |
dc.contributor.author | Shiao C.-C. | en_US |
dc.contributor.author | Tsai P.-R. | en_US |
dc.contributor.author | Hu F.-C. | en_US |
dc.contributor.author | NAI-KUAN CHOU | en_US |
dc.contributor.author | Ko W.-J. | en_US |
dc.contributor.author | KWAN-DUN WU | en_US |
dc.creator | Lai C.-F.;Wu V.-C.;Huang T.-M.;Yeh Y.-C.;Wang K.-C.;Han Y.-Y.;Lin Y.-F.;Jhuang Y.-J.;Chao C.-T.;Shiao C.-C.;Tsai P.-R.;Hu F.-C.;Nai-Kuan Chou;Ko W.-J.;Wu K.-D. | - |
dc.date.accessioned | 2020-03-09T07:30:44Z | - |
dc.date.available | 2020-03-09T07:30:44Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1364-8535 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863702457&doi=10.1186%2fcc11419&partnerID=40&md5=4f75dd29bb7d4b054c102325f9efb49d | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/474223 | - |
dc.description.abstract | Introduction: The adverse consequences of a non-dialysis-requiring acute kidney injury (AKI) are unclear. This study aimed to assess the long-term prognoses for critically ill patients experiencing a non-dialysis-requiring AKI.Methods: This retrospective observational cohort study investigated non-dialysis-requiring AKI survivors in surgical intensive care units between January 2002 and June 2010. All longitudinal post-discharge serum creatinine measurements and information regarding end-stage renal disease (ESRD) and death were collected. We assessed the long-term outcomes of chronic kidney disease (CKD), ESRD and all-cause mortality beyond discharge.Results: Of the 922 identified critically ill patients with a non-dialysis-requiring AKI, 634 (68.8%) patients who survived to discharge were enrolled. A total of 207 patients died after a median follow-up of 700.5 days. The median intervals between the onset of the AKI and the composite endpoints "stage 3 CKD or death", "stage 4 CKD or death", "stage 5 CKD or death", and "ESRD or death" were 685, 1319, 1743, and 2048 days, respectively. This finding shows a steady long-term decline in kidney function after discharge. Using the multivariate Cox proportional hazard model, we found that every 1 mL/min/1.73 m 2decrease from baseline estimated glomerular filtration rate (eGFR) of individuals who progressed to stage 3, 4, and 5 CKD increased the risks of long-term mortality by 0.7%, 2.3%, and 4.1%, respectively (all p < 0.05). This result indicates that the mortality risk increased significantly in a graded manner as kidney function declined from the baseline eGFR to advanced stages of CKD during the follow-up period.Conclusions: In critically ill patients who survive a non-dialysis-requiring AKI, there is a need for continuous monitoring and kidney function protection beyond discharge. ? 2012 Lai et al.; licensee BioMed Central Ltd. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Critical Care | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | creatinine; creatinine; acute kidney failure; adolescent; adult; aged; article; chronic kidney disease; cohort analysis; creatinine blood level; critically ill patient; female; follow up; glomerulus filtration rate; hospital discharge; human; intensive care unit; kidney dysfunction; kidney failure; longitudinal study; major clinical study; male; mortality; non dialysis requiring acute kidney injury; observational study; outcome assessment; priority journal; prognosis; proportional hazards model; retrospective study; risk factor; survivor; Acute Kidney Injury; blood; comorbidity; critical illness; disease course; hospital mortality; Kidney Failure, Chronic; kidney function test; middle aged; pathophysiology; survival analysis; Taiwan; treatment outcome; very elderly; Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Comorbidity; Creatinine; Critical Illness; Disease Progression; Female; Hospital Mortality; Humans; Intensive Care Units; Kidney Failure, Chronic; Kidney Function Tests; Male; Middle Aged; Retrospective Studies; Survival Analysis; Survivors; Taiwan; Treatment Outcome | - |
dc.title | Kidney function decline after a non-dialysis-requiring acute kidney injury is associated with higher long-term mortality in critically ill survivors | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1186/cc11419 | - |
dc.identifier.pmid | 22789111 | - |
dc.relation.journalvolume | 16 | en_US |
dc.relation.journalissue | 4 | en_US |
item.openairetype | journal article | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUHHC | - |
crisitem.author.dept | Anesthesiology-NTUH | - |
crisitem.author.dept | Anesthesiology | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Anesthesiology | - |
crisitem.author.dept | Traumatology-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUHBH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-2109-1522 | - |
crisitem.author.orcid | 0000-0001-7935-0991 | - |
crisitem.author.orcid | 0000-0002-9387-0798 | - |
crisitem.author.orcid | 0000-0001-5143-5520 | - |
crisitem.author.orcid | 0000-0002-4083-4689 | - |
crisitem.author.orcid | 0000-0001-8831-7835 | - |
crisitem.author.orcid | 0000-0002-4350-7755 | - |
crisitem.author.orcid | 0000-0003-2892-7986 | - |
crisitem.author.orcid | 0000-0001-5494-7708 | - |
crisitem.author.orcid | 0000-0002-3339-1509 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital Bei-Hu Branch | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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