https://scholars.lib.ntu.edu.tw/handle/123456789/474476
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang J.-H. | en_US |
dc.contributor.author | Chen J.-C. | en_US |
dc.contributor.author | Hsu C.-J. | en_US |
dc.contributor.author | WEI-SHIUNG YANG | en_US |
dc.contributor.author | TIEN-CHEN LIU | en_US |
dc.creator | TIEN-CHEN LIU;Yang W.-S.;Hsu C.-J.;Chen J.-C.;Hwang J.-H. | - |
dc.date.accessioned | 2020-03-09T09:11:22Z | - |
dc.date.available | 2020-03-09T09:11:22Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0197-4580 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863495842&doi=10.1016%2fj.neurobiolaging.2011.10.012&partnerID=40&md5=b6f2c365b60731be17ac3b4e097352af | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/474476 | - |
dc.description.abstract | To investigate the relationship between plasma reactive oxygen species (ROS) levels and severity of age-related hearing impairment in humans. We recruited 302 adult subjects aged 40-77 years with normal or symmetrical sensorineural hearing loss. The association of plasma ROS levels on pure tone average of low frequencies (PTA-low) and pure tone average of high frequencies (PTA-high) were analyzed. Luminol-dependent chemiluminescence signals, which reflect hydrogen peroxide (H2O2), hypochlorite (HOCl/OCl-) and hydroxyl radicals (?OH) levels, showed significant positive association with PTA-low and PTA-high after adjusting for age, gender, central obesity, systemic diseases, and health-related habits (smoking, drinking, antioxidant intake). Lucigenin-dependent chemiluminescence signals, which mainly reflect superoxide anion (O2?-) levels, showed significant positive association with PTA-low, but not with PTA-high after adjusting for other variables. We concluded that plasma ROS levels were associated with severity of age-related hearing impairment in humans. Various ROS may differently affect auditory dysfunctions. ? 2012 Elsevier Inc. | - |
dc.relation.ispartof | Neurobiology of Aging | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | reactive oxygen metabolite; adult; age; aged; article; auditory threshold; disease association; disease severity; female; genetic risk; hearing impairment; human; lifestyle; low frequency noise; major clinical study; male; priority journal; pure tone audiometry; systemic disease; Adult; Aged; Aging; Analysis of Variance; Audiometry, Pure-Tone; Auditory Threshold; Body Height; Body Weight; Female; Hearing Loss; Humans; Hydrogen Peroxide; Hydroxyl Radical; Hypochlorous Acid; Male; Middle Aged; Reactive Oxygen Species; Retrospective Studies | - |
dc.title | Plasma reactive oxygen species levels are correlated with severity of age-related hearing impairment in humans | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.neurobiolaging.2011.10.012 | - |
dc.identifier.pmid | 22133279 | - |
dc.identifier.scopus | 2-s2.0-84863495842 | - |
dc.relation.pages | 1920-1926 | - |
dc.relation.journalvolume | 33 | - |
dc.relation.journalissue | 9 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Otolaryngology | - |
crisitem.author.dept | Otolaryngology-NTUH | - |
crisitem.author.orcid | 0000-0001-5087-373X | - |
crisitem.author.orcid | 0000-0001-6771-5025 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
Appears in Collections: | 醫學系 |
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